Abstract
A series of twelve novel isoxazole analogs containing dibenzosuberane moiety were synthesized using convergent synthesis approach. Newly synthesized compounds were well characterized by mass spectroscopy, IR and NMR spectroscopy. All the compounds were screened for their antiproliferative property against HepG2 and HeLa cell lines. Among them, compounds 7a, 7b, 7c, 7g and 7h were found active against both HepG2 and HeLa cell lines.
Graphical Abstract
Twelve analogs of isoxazole containing dibenzosuberane moiety (7a–l) were synthesized, characterized and evaluated for their antiproliferative activity.
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Acknowledgments
This work was carried out as part of Mr. Manjunath Moger’s Ph.D. work. The authors are grateful to Advinus Therapeutics Ltd, Bangalore, India, for the support and encouragement to higher education. The authors also thank the Department of Chemistry, Mangalore University, India.
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Moger, M., Pradhan, A., Singh, A. et al. Synthesis and antiproliferative properties of isoxazole analogs containing dibenzosuberane moiety. Med Chem Res 25, 449–455 (2016). https://doi.org/10.1007/s00044-015-1497-3
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DOI: https://doi.org/10.1007/s00044-015-1497-3