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Cytotoxic and antibacterial activities of two new triterpenoids from the peels of local Egyptian Malus domestica L.

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Abstract

The local Egyptian peels of Malus domestica were extracted successively with absolute ethanol and partitioned sequentially with n-hexane, chloroform and methanol. Friedelin (1) was isolated from the n-hexane fraction and betulinic acid (2) from the chloroform fraction. The new compounds 2α-hydroxy-3-oxo-lup-12(13), 20(29)-dien-27, 28-dioic acid (3) and 2α, 27-dihydroxy-3-oxo-lup-12(13), 20(29)-dien-28-oic acid (4) were isolated from the methanol fraction and elucidated by spectroscopic data interpretation. Friedelin (1) and betulinic acid (2) are known compounds that are newly identified from peels of Malus domestica. Among them, compounds (3) and (4) exhibited cytotoxic activity against the breast carcinoma and human colon carcinoma cells, with (4) being slightly most potent toward the breast carcinoma, while (3) being slightly most potent toward the human colon carcinoma cells.

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Acknowledgments

Many thanks for Greece Government, which enabled me study post doctor for 9-month on Natural Product and Natural Product Synthesis at the Lab. of Organic Chemistry, Department of Chemistry, Faculty of science, Aristotle University of Thessaloniki, Greece. Also, I would like to thank the staff members of Department of Chemistry at Faculty of Sciences, Aristotle University of Thessaloniki for the performance of some 1D&2D NMR&MS spectral analysis experiments. Many thanks for the staff of Pharmaceutical Sciences in Faculty of Pharmacy, Aristotle University of Thessaloniki for the performance of antimicrobial assay. The author thanks Egypt Government for fund and Zagazig University for financial support.

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Authors and Affiliations

  1. Faculty of Specific Education, Zagazig University, Zagazig, 44519, Egypt

    Yasser Selim

  2. Department of Chemistry, Faculty of Science, Aristotle University of Thessaloniki, Thessaloníki, Greece

    Konstantinous Litinas

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  1. Yasser Selim
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  2. Konstantinous Litinas
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Correspondence to Yasser Selim.

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Selim, Y., Litinas, K. Cytotoxic and antibacterial activities of two new triterpenoids from the peels of local Egyptian Malus domestica L.. Med Chem Res 24, 4016–4022 (2015). https://doi.org/10.1007/s00044-015-1451-4

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  • DOI: https://doi.org/10.1007/s00044-015-1451-4

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