Abstract
A series of chalconyl-incorporated hydrazone derivatives of mefenamic acid was synthesized in order to obtain new compounds with potential analgesic and anti-inflammatory activity having lesser side effects. The structures of all synthesized compounds were confirmed by means of elemental analysis, IR, 1H NMR, 13C NMR and mass spectra. All compounds were evaluated for their analgesic and anti-inflammatory activities by tail-flick method and carrageenan-induced rat paw edema test, respectively. Among all the synthesized compounds, compounds (4a) and (4j) exhibited the most prominent and consistent anti-inflammatory activity. In acute ulcerogenicity study, it can be concluded that compounds (4a) and (4j) are devoid of the deadlier gastrointestinal toxicities.
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Acknowledgments
The authors deeply appreciate the assistance of the Department of Pharmacology, B N College of Pharmacy, Udaipur, India, in the biological screening of the compounds. The authors also deeply appreciate the Punjab University, Punjab, India, for providing the spectral studies.
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Kumar, N., Chauhan, L.S., Sharma, C.S. et al. Synthesis, analgesic and anti-inflammatory activities of chalconyl-incorporated hydrazone derivatives of mefenamic acid. Med Chem Res 24, 2580–2590 (2015). https://doi.org/10.1007/s00044-015-1318-8
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DOI: https://doi.org/10.1007/s00044-015-1318-8