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Medicinal Chemistry Research

, Volume 24, Issue 5, pp 1777–1788 | Cite as

Synthesis and cytotoxic evaluation for some new 2,5-disubstituted pyrimidine derivatives for anticancer activity

  • Onteddu Surendranatha Reddy
  • Ch. Venkata Suryanarayana
  • K. J. P. Narayana
  • V. Anuradha
  • B. Hari BabuEmail author
Review Article

Abstract

An efficient synthetic approach for 2,5-disubstituted pyrimidines has been reported. The desired 2,5-substituted pyrimidines were obtained by Suzuki coupling of 2-substituted benzyloxy-5-bromopyrimidines with various aryl boronic acids in the presence catalytic amount of PdCl2(PPh3)2 with 0.5 M aqueous Na2CO3 in water at 80 °C. 2-Benzyloxy-5-bromopyrimidines were synthesized, in turn by the reaction of 2-chloro-5-bromopyrimidine with substituted benzyl alcohols in the presence of Cs2CO3 in CH3CN:DMF (1:1). Some of the 2,5-disubstituted pyrimidines have shown moderate in vitro cytotoxic activity against HeLa cell line.

Graphical Abstract

Keywords

2-Chloro-5-bromopyrimidine Cesium carbonate Green synthesis HeLa cell line PdCl2(PPh3)2 

Notes

Acknowledgments

The authors are highly thankful to Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur, and Andhra Pradesh, India for constant encouragement.

Supplementary material

44_2014_1276_MOESM1_ESM.docx (2.4 mb)
Copies of 1H and 13C NMR spectra for all the new compounds

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Onteddu Surendranatha Reddy
    • 1
  • Ch. Venkata Suryanarayana
    • 2
  • K. J. P. Narayana
    • 3
  • V. Anuradha
    • 2
  • B. Hari Babu
    • 1
    Email author
  1. 1.Department of ChemistryAcharya Nagarjuna UniversityGunturIndia
  2. 2.Department of ChemistryVignan School of P.G. StudiesGunturIndia
  3. 3.Department of MicrobiologyAcharya Nagarjuna UniversityGunturIndia

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