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An efficient and eco-friendly synthesis and evaluation of antibactrial activity of pyrano[2,3-c]pyrazole derivatives

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Abstract

A rapid, straightforward, and highly efficient one-pot synthesis of pyrano[2,3-c]pyrazole derivatives and spiro-conjugated pyrano[2,3-c]pyrazole has been developed based on newly introduced and environmentally benign Brønsted-acidic ionic liquid catalyst [DMBSI]HSO4 via one-pot four-component reaction under solvent-free conditions. The synthesized compounds were screened for their antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria.

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Acknowledgments

The authors are grateful to the Research Council of University of Guilan for the partial financial support of this research work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

    Manouchehr Mamaghani, Roghayeh Hossein Nia, Farhad Shirini & Khalil Tabatabaeian

  2. Department of Biology, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

    Mehdi Rassa

Authors
  1. Manouchehr Mamaghani
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  2. Roghayeh Hossein Nia
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  3. Farhad Shirini
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  4. Khalil Tabatabaeian
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  5. Mehdi Rassa
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Corresponding author

Correspondence to Manouchehr Mamaghani.

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Mamaghani, M., Hossein Nia, R., Shirini, F. et al. An efficient and eco-friendly synthesis and evaluation of antibactrial activity of pyrano[2,3-c]pyrazole derivatives. Med Chem Res 24, 1916–1926 (2015). https://doi.org/10.1007/s00044-014-1271-y

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  • DOI: https://doi.org/10.1007/s00044-014-1271-y

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