Medicinal Chemistry Research

, Volume 24, Issue 5, pp 1916–1926 | Cite as

An efficient and eco-friendly synthesis and evaluation of antibactrial activity of pyrano[2,3-c]pyrazole derivatives

  • Manouchehr MamaghaniEmail author
  • Roghayeh Hossein Nia
  • Farhad Shirini
  • Khalil Tabatabaeian
  • Mehdi Rassa
Original Research


A rapid, straightforward, and highly efficient one-pot synthesis of pyrano[2,3-c]pyrazole derivatives and spiro-conjugated pyrano[2,3-c]pyrazole has been developed based on newly introduced and environmentally benign Brønsted-acidic ionic liquid catalyst [DMBSI]HSO4 via one-pot four-component reaction under solvent-free conditions. The synthesized compounds were screened for their antibacterial activities against both gram-negative (Pseudomonas aeruginosa and Escherichia coli) and gram-positive (Micrococcus luteus and Bacillus subtilis) bacteria.

Graphical Abstract


Hydrazine hydrate Pyrano[2,3-c]pyrazole Solvent-free Ionic liquid Antibacterial Spiro 



The authors are grateful to the Research Council of University of Guilan for the partial financial support of this research work.

Supplementary material

44_2014_1271_MOESM1_ESM.pdf (7.4 mb)
Supplementary material 1 (PDF 7598 kb)


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Manouchehr Mamaghani
    • 1
    Email author
  • Roghayeh Hossein Nia
    • 1
  • Farhad Shirini
    • 1
  • Khalil Tabatabaeian
    • 1
  • Mehdi Rassa
    • 2
  1. 1.Department of Chemistry, Faculty of SciencesUniversity of GuilanRashtIran
  2. 2.Department of Biology, Faculty of SciencesUniversity of GuilanRashtIran

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