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Study of new β-lactams-substituted s-triazine derivatives as potential bioactive agents

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Abstract

In our continuous effort toward synthesis of potential bioactive agents, two series of benzonitriles/nicotinonitriles endowed with β-lactams bound to s-triazine skeleton were synthesized by applying an efficient palladium catalyzed C–C Suzuki coupling reaction. The synthesized compounds were screened for their in vitro antimicrobial against different human pathogenic microorganisms and prostate cancer PC3 cells. Some compounds displayed remarkable antimicrobial activity and noticeable anticancer activity. It was observed that both benzonitrile and nicotinonitrile sets are essential to increase the different pharmacological activities. The new synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, and MS analysis.

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Acknowledgments

The authors are thankful to Director, S. V. National Institute of Technology, Surat for the scholarship, encouragement, and facilities. We wish to offer our deepest gratitude to Microcare Laboratory, Surat, India and Tata Memorial Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, India for carrying out the biological screenings. We are also thankful to SAIF Panjab University and Centre of Excellence, Vapi, India for spectral analyses.

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Authors and Affiliations

  1. Department of Applied Chemistry, S. V. National Institute of Technology, Surat, 395007, India

    Amit B. Patel & Premlata Kumari

  2. Department of Chemistry, School of Science, Gujarat University, Ahmedabad, 380009, India

    Kishor H. Chikhalia

Authors
  1. Amit B. Patel
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  2. Kishor H. Chikhalia
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  3. Premlata Kumari
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Correspondence to Amit B. Patel, Kishor H. Chikhalia or Premlata Kumari.

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Patel, A.B., Chikhalia, K.H. & Kumari, P. Study of new β-lactams-substituted s-triazine derivatives as potential bioactive agents. Med Chem Res 24, 468–481 (2015). https://doi.org/10.1007/s00044-014-1151-5

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  • DOI: https://doi.org/10.1007/s00044-014-1151-5

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