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Effect of garlic and cabbage on healing of gastric ulcer in experimental rats

Medicinal Chemistry Research volume 23, pages 5110–5119 (2014)Cite this article

Abstract

The effect of garlic (Allium sativum) and cabbage (Brassica oleracea var. capitata) extracts on the healing of gastric ulcer in experimental rats has been investigated. Thirty-three albino male rats (115 ± 4 g B.Wt. each) were used and divided into 6 groups (n = 6 rats); one was used as a negative control while the others were given aspirin orally (200 mg/kg B.Wt.). One of these groups was employed as a positive control and the others were administrated with 150 or 300 mg/kg B.Wt. doses of garlic and cabbage juice for 7 days. The length of the gastric ulcer, the volume of gastric juice, the total acidity, the pH value, the total bacterial count, and the histopathological changes of the stomach were examined. Results revealed that oral administration with both tested plant extracts reduced the length of gastric ulcer, the total acidity, the volume of gastric juice, the bacterial count, and the histopathological changes caused by aspirin. On the other hand, both aqueous plants extract increased the pH value of gastric juice. It is concluded that, garlic and cabbage extract could be used for healing acute gastric ulcer.

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Acknowledgments

The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project Number RGP- VPP- 007.

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Authors and Affiliations

  1. Laboratoire Chimie Matériaux, FSO, Université Mohammed 1er, 60000, Oujda, Morocco

    Taibi Ben Hadda

  2. Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Naser A. ElSawy

  3. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, Saudi Arabia

    Naser A. ElSawy

  4. Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al Qura University, Makkah, Saudi Arabia

    Eslam A. M. Header

  5. Department of Nutrition and Food Science, Faculty of Home Economics, Minufiya University, Shebin El Kom, Egypt

    Eslam A. M. Header

  6. Department of Chemistry, Faculty of Science, King Saud University, Riyadh, Saudi Arabia

    Yahia N. Mabkhot

  7. Department of Chemistry, The University of Jordan, Amman, 11942, Jordan

    Mohammad S. Mubarak

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  1. Taibi Ben Hadda
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  2. Naser A. ElSawy
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  3. Eslam A. M. Header
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Correspondence to Taibi Ben Hadda or Naser A. ElSawy.

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Ben Hadda, T., ElSawy, N.A., Header, E.A.M. et al. Effect of garlic and cabbage on healing of gastric ulcer in experimental rats. Med Chem Res 23, 5110–5119 (2014). https://doi.org/10.1007/s00044-014-1092-z

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  • DOI: https://doi.org/10.1007/s00044-014-1092-z

Keywords

  • Garlic (Allium sativum)
  • Cabbage (Brassica oleracea var. capitata) juice
  • Aspirin ulcer
  • Histopathological changes
  • pH value
  • Bacterial count
  • Gastric juice