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Chemoselective N-benzylation of 2-thiohydantoins and 2-thiobarbituric acids catalyzed by PEG-stabilized Ni nanoparticles and their anti-microbial activities

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Abstract

An efficient one pot chemoselective N-benzylation of 2-thiohydantoins and 2-thiobarbituric acids catalyzed by PEG-stabilized Ni nanoparticles has been reported, wherein the NH group of thiohydantoins and thiobarbituric acids is selectively benzylated and no S-benzylation is observed. Mildness and environment friendly approach of the protocol gives it an edge over other conventional methods. These compounds were tested in vitro for their antibacterial activity against Gram-positive bacteria namely, Staphylococcus aureus and Bacillus subtilis and their inhibitory action against two strains of fungus.

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Acknowledgments

Sneha is thankful to CSIR, New Delhi, India for the award of Junior and Senior Research Fellowship.

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Authors and Affiliations

  1. Department of Chemistry, University of Delhi, Delhi, 110007, India

    Sneha & Jitender M. Khurana

  2. Department of Microbiology, Kurukshetra University, Kurukshetra, 136119, Haryana, India

    Chetan Sharma & K. R. Aneja

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  1. Sneha
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  2. Jitender M. Khurana
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  3. Chetan Sharma
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  4. K. R. Aneja
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Correspondence to Jitender M. Khurana.

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Sneha, Khurana, J.M., Sharma, C. et al. Chemoselective N-benzylation of 2-thiohydantoins and 2-thiobarbituric acids catalyzed by PEG-stabilized Ni nanoparticles and their anti-microbial activities. Med Chem Res 23, 4595–4606 (2014). https://doi.org/10.1007/s00044-014-1008-y

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  • DOI: https://doi.org/10.1007/s00044-014-1008-y

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