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Cu(II) and Ni(II) complexes of coumarin derivatives with fourth generation flouroquinolone: synthesis, characterization, microbicidal and antioxidant assay

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Abstract

New Cu(II) and Ni(II) complexes of acetyl coumarin derivatives with gatifloxacin were synthesized. Characterization of the complexes was carried out by elemental analysis, FT-IR, FAB-MS, electronic spectra and magnetic measurement along with thermo gravimetric studies. Thermal study reveals the absence of coordinated water molecule in case of Cu(II) complexes. All the Cu(II) complexes were found more potent antibacterial activity compared to Ni(II) complexes. The antituberculosis data have shown that copper conjugation may be advantageous in designing highly effective drugs for antitubercular therapy. These complexes were also found to be potent antioxidizing agents comprising radical scavenging capability and ferric reducing abilities.

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Acknowledgments

We articulate our appreciation to authorities of V. P. & R. P. T. P. Science College, Sardar Patel University, Vallabh Vidyanagar, India for providing infrastructural & chemical facilities. We are greatful to Department of Science and Technology (DST) Delhi, India for providing financial support to one of the author (JDB) in the form of INSPIRE fellowship. We are thankful to the Director, SICART, Vallabh Vidyanagar for spectral analysis facility. Authors are also grateful to the Microcare laboratory, Surat for providing bio-analysis facility.

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  1. V. P. & R. P. T. P. Science College, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India

    Jiten Patel, Hitesh Dholariya, Ketan Patel, Jaimin Bhatt & Kanuprasad Patel

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  1. Jiten Patel
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  2. Hitesh Dholariya
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Correspondence to Kanuprasad Patel.

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Patel, J., Dholariya, H., Patel, K. et al. Cu(II) and Ni(II) complexes of coumarin derivatives with fourth generation flouroquinolone: synthesis, characterization, microbicidal and antioxidant assay. Med Chem Res 23, 3714–3724 (2014). https://doi.org/10.1007/s00044-014-0943-y

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