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Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes

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Abstract

The new Schiff base ligand (1-[[1-(5-chloro-2-hydroxyphenyl)ethyliden]amino]-4-phenyl-5-benzoyl-pyrimidine-2-thione) and its Cu(II), Co(II), Pd(II), and Mn(II) complexes were synthesized and characterized by elemental and molar conductance, UV–Vis, IR, NMR spectra, magnetic moment as well as mass spectra. While Pd(II) complexes exhibited square planar geometry, the others displayed octahedral geometry. The complexes showed nonelectrolytic behavior. All the compounds were evaluated for in vitro antimicrobial efficiency against Gram-positive bacteria, Gram-negative bacteria, and yeast using microdilution procedure. This study suggested that the [Co(L)2]·3H2O (1b) and [Mn(L)2]·2H2O (1d) complexes might be new potential antimicrobial substances against bacteria and fungi.

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Acknowledgments

We are grateful to Presidency of Scientific Research Projects of University Gaziantep (FEF-10-09) for the support of this research.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Arts, Gaziantep University, 27310, Gaziantep, Turkey

    Mehmet Sönmez, Hatice Gamze Sogukomerogullari & Feyza Öztemel

  2. Department of Biology, Faculty of Science and Arts, Sinop University, 57010, Sinop, Turkey

    İsmet Berber

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  1. Mehmet Sönmez
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  2. Hatice Gamze Sogukomerogullari
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  3. Feyza Öztemel
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  4. İsmet Berber
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Correspondence to Mehmet Sönmez.

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Sönmez, M., Sogukomerogullari, H.G., Öztemel, F. et al. Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes. Med Chem Res 23, 3451–3457 (2014). https://doi.org/10.1007/s00044-014-0925-0

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  • DOI: https://doi.org/10.1007/s00044-014-0925-0

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