Medicinal Chemistry Research

, Volume 23, Issue 3, pp 1290–1299 | Cite as

Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents

Original Research

Abstract

Benzimidazole analogs bearing electron-withdrawing as well as electron-donating substituent were synthesized to achieve bioactive molecules with significant antimicrobial property. The desired compounds were prepared by multi-step synthesis process. The formation of intermediates and their corresponding derivatives (III113) was confirmed by spectral characterization such as 1H NMR, 13C NMR, mass spectra, IR, and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel of Gram-positive and Gram-negative bacteria as well as fungi. From the SAR study data, it was observed that the derivatives with electron-withdrawing functional groups were more bioactive than that with electron-donating functional groups.

Keywords

Benzimidazole Antifungal Antibacterial MIC SAR study 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Chemistry Research Laboratory, Chemistry DivisionSheth M. N. Science CollegePatanIndia

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