Greener synthesis and photo-antiproliferative activity of novel fluorinated benzothiazolo[2, 3-b]quinazolines
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1-Butyl-3-methylimidazolium and inorganic anions such as BF4 −, PF6 − and PTSA− are used as green catalyst and reaction medium for synthesis of fluorinated benzothiazolo[2,3-b]quinazoline-2H-ones analogues via one-pot reaction of 2-amino-6-chlorobenzothiazole (1), fluorinated aldehydes (2) dimedone and (3) using microwave irradiation. The whole procedure is simple and straightforward, and no aqueous work-up is needed. Synthesized compounds are screened for photo-antiproliferative activity against human keratinocytes cell line and carcinoma cell lines like promyelocytic leukemia (HL-60) cells and adenocarcinoma (LoVo) cells. Structure activity relationship studies revealed that the substitution on aryl ring played a dominant role and was responsible for the antiproliferative activity.
KeywordsIonic liquid Fluorinated benzothiazolo[2,3-b]quinazolines Microwaves Antiproliferative activity
KA acknowledge the D.S.T. (SR/FT/CS-69/2013), New Delhi, India and University of Delhi, Delhi, India for financial support.
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