Medicinal Chemistry Research

, Volume 22, Issue 10, pp 4654–4662 | Cite as

Synthesis and antifungal activity of novel 7-O-substituted pyridyl-4-methyl coumarin derivatives

  • Xiaoyun Chai
  • Shichong Yu
  • Xiaoyan Wang
  • Nan Wang
  • Zhanzhou Zhu
  • Dazhi Zhang
  • Qiuye Wu
  • Yongbing Cao
  • Qingyan Sun
Original Research

Abstract

A new series of 7-O-substituted pyridyl-4-methyl coumarin derivatives were synthesized and characterized based on their spectral data. All the target compounds were evaluated for their in vitro antifungal activity against eight important fungal pathogens. This study showed that the introduction of the substituted pyridyl moiety at the 7-hydroxy position of coumarin could enhance the antifungal activities. It also indicated that a bulky substituent was not beneficial to the antifungal activity of those coumarin derivatives.

Keywords

Coumarin derivatives Synthesis Antifungal activity Pechmann reaction 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Xiaoyun Chai
    • 1
  • Shichong Yu
    • 1
  • Xiaoyan Wang
    • 2
  • Nan Wang
    • 3
  • Zhanzhou Zhu
    • 3
  • Dazhi Zhang
    • 1
  • Qiuye Wu
    • 1
  • Yongbing Cao
    • 4
  • Qingyan Sun
    • 1
  1. 1.Department of Organic ChemistrySchool of Pharmacy, Second Military Medical UniversityShanghaiPeople’s Republic of China
  2. 2.Center for Laboratory TeachingSchool of Pharmacy, Second Military Medical UniversityShanghaiPeople’s Republic of China
  3. 3.Pharmacy Team, Administrative Brigade of PostgraduateSecond Military Medical UniversityShanghaiPeople’s Republic of China
  4. 4.Drug Research Center, School of Pharmacy, Second Military Medical UniversityShanghaiPeople’s Republic of China

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