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Synthesis, molecular docking studies, and in vitro screening of sulfanilamide-thiourea hybrids as antimicrobial and urease inhibitors

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Abstract

A series of novel hybrid molecules containing sulfanilamide and thiourea templates was designed and synthesized. These compounds were screened for antimicrobial and urease inhibitory activities. Some of the compounds revealed promising antibacterial and antifungal activities. Fascinatingly, the majority of the compounds exhibited potential urease inhibitory activities with IC50 ranging from 0.20 to 7.50 μM. Compound 2b was identified as the most potent urease inhibitor (IC50 0.20 μM), and was 100-fold more potent than thiourea, the standard inhibitor. Molecular docking studies of compounds were performed on 3D crystal structures of Jack bean and Helicobacter pylori ureases.

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Acknowledgments

This study was financially supported by COMSTECH–TWAS and German-Pakistani Research Collaboration Programme to JI.

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Authors and Affiliations

  1. Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan

    Aamer Saeed & Amara Mumtaz

  2. Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

    Sumera Zaib, Arshid Pervez & Jamshed Iqbal

  3. Department of Bioinformatics, Fraunhofer Institute SCAI, Sankt Augustin, Germany

    Mohammad Shahid

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  1. Aamer Saeed
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  2. Sumera Zaib
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  3. Arshid Pervez
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  4. Amara Mumtaz
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  6. Jamshed Iqbal
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Correspondence to Jamshed Iqbal.

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Saeed, A., Zaib, S., Pervez, A. et al. Synthesis, molecular docking studies, and in vitro screening of sulfanilamide-thiourea hybrids as antimicrobial and urease inhibitors. Med Chem Res 22, 3653–3662 (2013). https://doi.org/10.1007/s00044-012-0376-4

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  • DOI: https://doi.org/10.1007/s00044-012-0376-4

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