Synthesis of novel benzimidazole derivatives: as potent analgesic agent
- 259 Downloads
1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols have been synthesized using o-phenylinediamine and naphthaldehyde in the presence of sodium hydride and THF. 1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols were evaluated for the analgesic activity by tail flick method in rats. Synthesized1-(1-alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols in doses of 50 mg/kg increased the pain threshold significantly after 0, 30, 60, 90, and 120 min of administration in the tail flick model. Compounds B3a, B2b, and B1b showed time-dependent action in all the experimental models. The present study indicates that Compounds B3a, B2b, and B1b show analgesic properties.
KeywordsBenzimidazole derivatives Analgesic activity Tail flick method Naphthalene derivatives
- Goud VM, Sreenivasulu N, Rao AS, Chigiri S (2011) Synthesis, antimicrobial and pharmacological evaluation of substituted novel benzimidazoles. Der Pharma Chemica 3:446–452Google Scholar
- Muthumani P, Meera R, Venkatraman S, Murugan, Devi P (2010) Synthesis and biological study of some novel Schiff’s bases of indazolone derivatives. J Chem Pharm Res 2:433–443Google Scholar
- Samudrala M, Thallada L, Thallada PK, Veerati PC (2011) Synthesis and anti-inflammatory activity of 2-[(1H-benzimidazole-2yl-methyl)sulfonyl]-n-(phenyl methylidine)acetohydrazide derivatives. Int J Res Pharm Chem 1:148–155Google Scholar
- Yepez-Mulia L, Hernandez-Luis F, Hernandez-Campos A, Castillo R, Navarrete-Vazquez G, Hernandez M, Soria-Arteche O (2010) Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis. Eur J Med Chem 45:3135–3140PubMedCrossRefGoogle Scholar