Medicinal Chemistry Research

, Volume 22, Issue 2, pp 900–904 | Cite as

Synthesis of novel benzimidazole derivatives: as potent analgesic agent

  • Shushank Dixit
  • Pramod Kumar Sharma
  • Niranjan Kaushik
Original Research


1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols have been synthesized using o-phenylinediamine and naphthaldehyde in the presence of sodium hydride and THF. 1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols were evaluated for the analgesic activity by tail flick method in rats. Synthesized1-(1-alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols in doses of 50 mg/kg increased the pain threshold significantly after 0, 30, 60, 90, and 120 min of administration in the tail flick model. Compounds B3a, B2b, and B1b showed time-dependent action in all the experimental models. The present study indicates that Compounds B3a, B2b, and B1b show analgesic properties.


Benzimidazole derivatives Analgesic activity Tail flick method Naphthalene derivatives 

Supplementary material

44_2012_83_MOESM1_ESM.pdf (1002 kb)
Supplementary material 1 (PDF 1001 kb)


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Shushank Dixit
    • 1
  • Pramod Kumar Sharma
    • 1
  • Niranjan Kaushik
    • 1
  1. 1.Department of Pharmaceutical TechnologyMeerut Institute of Engineering and TechnologyMeerutIndia

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