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α,α-Dibromoacetophenones mediated synthesis of some new 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines and their antimicrobial evaluation

Abstract

A series of new 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines (3, 4) were synthesized by the reaction of various α,α-dibromoacetophenones 1 with 3-alkyl/phenyl-4-amino-5-mercapto-s-triazoles (2) in different alcoholic solvents in good yields. All the newly synthesized compounds (3, 4) were screened for their in vitro antibacterial and antifungal activity. Biological activities of these compounds were compared with those of the commercially available antibiotic, ciprofloxacin and antifungal agent, amphotericin-B. The title compounds showed good activity against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis and the yeasts, Saccharomyces cerevisiae and Candida albicans.

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Acknowledgments

The authors are indebted to UGC/CSIR for providing research fellowship to Ms.Vijay Kiran for carrying out this study. The authors also thanks USIC, University of Delhi, Delhi, India for elemental analysis.

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Correspondence to Rashmi Pundeer.

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Pundeer, R., Kiran, V., Prakash, R. et al. α,α-Dibromoacetophenones mediated synthesis of some new 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines and their antimicrobial evaluation. Med Chem Res 21, 4043–4052 (2012). https://doi.org/10.1007/s00044-011-9945-1

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Keywords

  • α,α-Dibromoacetophenones
  • 7H-7-alkoxy-3-alkyl/phenyl-6-aryl-s-triazolo[3,4-b][1,3,4]thiadiazines
  • 3-alkyl/phenyl-4-amino-5-mercapto-s-triazoles
  • Antibacterial activity
  • Antifungal activity