Medicinal Chemistry Research

, Volume 21, Issue 12, pp 3973–3983 | Cite as

Synthesis and antimicrobial activity of novel derivatives of Biginelli pyrimidines

  • Bita Sedaghati
  • Afshin Fassihi
  • Shirin Arbabi
  • Mahnaz Ranjbar
  • Hamid Reza Memarian
  • Lotfollah Saghaie
  • Adel Omidi
  • Alireza Sardari
  • Mohammad Jalali
  • Daryoush Abedi
Original Research

Abstract

A series of novel Biginelli pyrimidines was prepared and evaluated for antimicrobial activity. Weak inhibitory activity (MIC = 128 μg/ml) was observed from 3b and 8b, against S. aureus and P. aeruginosa, respectively. Moderate antifungal agents: 4c, 4d, 4e with MIC = 32 μg/ml, 3d, 7b, and 8b with MIC = 64 μg/ml against C.albicans were determined. 4c, 4d, 4e, and 7b proved to be moderate antifungals against A. niger with MIC = 64 μg/ml.

Keywords

Antibacterial activity Antifungal activity 1,2,3,4-Tetrahydropyrimidine-5-carboxamides 1,2,3,4-Tetrahydropyrimidine-5-carboxylate esters 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Bita Sedaghati
    • 1
  • Afshin Fassihi
    • 1
  • Shirin Arbabi
    • 1
  • Mahnaz Ranjbar
    • 2
  • Hamid Reza Memarian
    • 2
  • Lotfollah Saghaie
    • 1
  • Adel Omidi
    • 1
  • Alireza Sardari
    • 1
  • Mohammad Jalali
    • 3
  • Daryoush Abedi
    • 4
  1. 1.Department of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIran
  2. 2.Department of Chemistry, Faculty of SciencesUniversity of IsfahanIsfahanIran
  3. 3.School of HealthIsfahan University of Medical SciencesIsfahanIran
  4. 4.Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIran

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