In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.
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This study was supported by the Doctor Research Start Foundation of Heilongjiang Bayi Agriculture University and the Project of Animal Good farming Innovation Team (SCX2011-10) of Heilongjiang Higher Education Committee.
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Sun, XY., He, XJ., Pan, CY. et al. Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives. Med Chem Res 21, 3692–3698 (2012). https://doi.org/10.1007/s00044-011-9922-8
- Forced swimming test
- Tail suspension test