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Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives

Medicinal Chemistry Research volume 21, pages 3692–3698 (2012)Cite this article

Abstract

In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.

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Acknowledgments

This study was supported by the Doctor Research Start Foundation of Heilongjiang Bayi Agriculture University and the Project of Animal Good farming Innovation Team (SCX2011-10) of Heilongjiang Higher Education Committee.

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Authors and Affiliations

  1. College of Animal Science and Technique, Heilongjiang Bayi Agriculture University, Daqing, 163319, Heilongjiang, China

    Xian-Yu Sun, Xian-Jing He, Chun-Yuan Pan, Yan-Peng Liu & Yun-Peng Zou

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  1. Xian-Yu Sun
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  2. Xian-Jing He
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Correspondence to Xian-Yu Sun.

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Sun, XY., He, XJ., Pan, CY. et al. Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives. Med Chem Res 21, 3692–3698 (2012). https://doi.org/10.1007/s00044-011-9922-8

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  • DOI: https://doi.org/10.1007/s00044-011-9922-8

Keywords

  • Tetrazole
  • Quinoline
  • Forced swimming test
  • Tail suspension test