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Synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory–antibacterial agents

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Abstract

The present article describes the synthesis of two novel series of thiosemicarbazones 3 and thiazolylhydrazinomethylidenepyrazoles 5. All the newly synthesized target compounds (3ae and 5ao) were screened for their in vivo anti-inflammatory (AI) activity using carrageenan-induced rat paw edema assay and in vitro antibacterial activity against two Gram-positive and two Gram-negative bacteria. Eight compounds (3bd, 5b, 5e, 5f, 5i, and 5o) showed consistently excellent AI activity (≥70% inhibition), at 3 and 4 h after the carrageenan injection, comparable to that of standard drug indomethacin (78%) whereas the remaining twelve compounds have shown significant activity with 57–75% inhibition after 3 h and 56–63% inhibition after 4 h. All the tested compounds showed moderate antibacterial properties.

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Acknowledgments

The authors (P. K. and N. C.) are grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi for the awards of junior and senior research fellowships, respectively. The authors are thankful to the Sophisticated Analytical Instrument Facility, Central Drug Research Institute, Lucknow for the Mass spectra facilities.

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Correspondence to Pawan K. Sharma.

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Kumar, P., Chandak, N., Kaushik, P. et al. Synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory–antibacterial agents. Med Chem Res 21, 3396–3405 (2012). https://doi.org/10.1007/s00044-011-9853-4

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  • DOI: https://doi.org/10.1007/s00044-011-9853-4

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