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Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives

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Abstract

Pyrazole derivatives IIal have been synthesized by condensation of chalcones Iaf with hydrazine hydrate and phenyl hydrazine under microwave irradiation in good yields. Oxadiazole derivatives IVaf have been synthesized by condensation of N′-hydroxypicolinamidine, N′-hydroxy isonicotinamidine, N′-hydroxypyrazine-2-carboxamidine with 2,5 dimethoxybenzaldehyde and 3-methoxy-4-hydroxy benzaldehyde, respectively. Structures assigned to IIal and IVaf are fully supported by correct spectral and analytical data. All compounds (IIal & IVaf) have been screened for anti-inflammatory and anticancer activities. Compounds IIj, IIk, and IVb exhibited good anti-inflammatory activity, while, IIa, c, j, and IVd showed better anticancer activity against four and three cancer cell lines, respectively.

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Acknowledgments

We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis and to Mr Rakesh Kumar (Integral Biosciences Ltd, Noida) for helping to use microwave reactor. Mr. Sandeep Kumar is thankful to MHRD New Delhi for financial assistance.

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Correspondence to Sham M. Sondhi.

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Sondhi, S.M., Kumar, S., Kumar, N. et al. Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives. Med Chem Res 21, 3043–3052 (2012). https://doi.org/10.1007/s00044-011-9850-7

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  • DOI: https://doi.org/10.1007/s00044-011-9850-7

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