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Synthesis of pyrazole-based 1,5-diaryl compounds as potent anti-inflammatory agents

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Abstract

Series of 1,5-diaryl pyrazole ester derivatives have been synthesized and found to contain potent inhibitory activity against cyclooxygenase-2 (COX-2) enzyme. The article describes synthesis of the target pyrazole analogs and biological assay using Carrageenan induced rat paw for investigation.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, 221 005, India

    Priyanka Shrivastava, Praveen Singh & Ashish Kumar Tewari

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  1. Priyanka Shrivastava
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  2. Praveen Singh
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  3. Ashish Kumar Tewari
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Correspondence to Ashish Kumar Tewari.

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Shrivastava, P., Singh, P. & Tewari, A.K. Synthesis of pyrazole-based 1,5-diaryl compounds as potent anti-inflammatory agents. Med Chem Res 21, 2465–2475 (2012). https://doi.org/10.1007/s00044-011-9774-2

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  • DOI: https://doi.org/10.1007/s00044-011-9774-2

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