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Medicinal Chemistry Research

, Volume 21, Issue 9, pp 2363–2367 | Cite as

Hypoglycemic effect of astaxanthin from shrimp waste in alloxan-induced diabetic mice

  • Juan-juan Wang
  • Zhi-qiang ChenEmail author
  • Wen-qing Lu
Original Research

Abstract

Hypoglycemic effect of astaxanthin obtained from shrimp waste was assessed in alloxan-induced diabetic and normal mice. Animals received oral administration of astaxanthin in dose of 5 and 10 mg/kg. The plasma glucose levels were examined and compared with that of metformin and gliclazide. Administration of astaxanthin (5 and 10 mg/kg) produced significantly fall on plasma glucose in alloxan-induced diabetic mice, while a slight fall in normal mice. In normal mice, postprandial hyperglycemia was significantly suppressed by oral administration of astaxanthin, which significantly lowered the postprandial area under curve. These results demonstrate that astaxanthin is effective in controlling hypoglycemia in animal model of type 1 diabetes mellitus. Therefore, astaxanthin can be a useful natural oral agent to treat diabetes.

Keywords

Hypoglycemic Astaxanthin Shrimp Alloxan Diabetes 

Notes

Acknowledgments

We are thankful to Tianjin University of Science & Technology for the partial support of this study. We also thank Academy of Military Medical Science for providing pharmacological laboratory facilities.

References

  1. Chew BP, Park JS, Wong MW, Wong TS (1999) A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res 19:1849–1853PubMedGoogle Scholar
  2. Chew BP, Park JS, Chyun JH, Maloney M, Line L (2003) Astaxanthin stimulates immune response in humans in a double-blind study. Paper presented at the Supply Side West SeminarGoogle Scholar
  3. Davie SJ, Gould BJ, Yudkin JS (1992) Effect of vitamin C on glycosylation of proteins. Diabetes 41:167–173PubMedCrossRefGoogle Scholar
  4. Hussein G, Nakamura M, Zhao Q, Iguchi T, Goto H, Sankawa U, Watanabe H (2005) Anti-hypertensive and neuroprotective effects of astaxanthin in experimental animals. Biol Pharm Bull 28:47–52PubMedCrossRefGoogle Scholar
  5. Kinp M (2009) Diet, gut, and type 1 diabetes: Role of wheat-derived peptides? Diabetes 58:1723–1724CrossRefGoogle Scholar
  6. Krinsky NI (1989) Antioxidant function of carotenoids. Free Radic Biol Med 7:617–635PubMedCrossRefGoogle Scholar
  7. Kurashige M, Okimasu E, Inoue M, Utsumi K (1990) Inhibition of oxidative injury of biological membranes by astaxanthin. Physiol Chem Phys Med NMR 22:27–38PubMedGoogle Scholar
  8. López-Cervantes JD, Sánchez-Machado I, Gutiérrez-Coronado MA, Ríos-Vázquez NJ (2006) Quantification of astaxanthin in shrimp waste hydrolysate by HPLC. Biomed Chromatogr 20:981–984PubMedCrossRefGoogle Scholar
  9. Lorenz RT, Cysewski GR (2000) Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol 18:160–167PubMedCrossRefGoogle Scholar
  10. McCune LM, Johns T (2002) Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the Indigenous Peoples of the North American boreal forest. J Ethnopharmacol 82:197–205PubMedCrossRefGoogle Scholar
  11. Murillo E (1992) Hypercholesterolemic effect of canthaxanthin and astaxanthin in rats. Arch Latinoam Nutr 42:409–413PubMedGoogle Scholar
  12. Naguib YMA (2000) Antioxidant activity of astaxanthin and related carotenoids. J Agric Food Chem 48:1150–1154PubMedCrossRefGoogle Scholar
  13. Naito Y, Uchiyama K, Aoi W, Hasegawa G, Nakamura N, Yoshida N, Maoka T, Takahashi J, Yoshikawa T (2004) Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors 20:49–59PubMedCrossRefGoogle Scholar
  14. O’Connor I, O’Brien N (1998) Modulation of UV-A light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts. J Dermatol Sci 16:226–230PubMedCrossRefGoogle Scholar
  15. Oberley LW (1988) Free radicals and diabetes. Free Radic Biol Med 5:113–124PubMedCrossRefGoogle Scholar
  16. Perry P (2008) One step closer to a cure. Interview: Saturday evening postGoogle Scholar
  17. Sinclair AJ, Girling AJ, Gray L, Lunec J, Barnett AH (1992) An investigation of the relationship between free radical activity and vitamin C metabolism in elderly diabetic subjects with retinopathy. Gerontology 38:268–274PubMedCrossRefGoogle Scholar
  18. Uchiyama K, Naito Y, Hasegawa G, Nakamura N, Takahashi J, Yoshikawa T (2002) Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice. Redox Rep 7:290–293PubMedCrossRefGoogle Scholar
  19. Yuan JP, Cheng F (1998) Chromatographic separation and purification of trans-astaxanthin from the extracts of Haematococcus pluvialis. J Agric Food Chem 46:3371–3375CrossRefGoogle Scholar
  20. Zhang XL, Pan LS, Wei XL, Gao H, Liu JG (2007) Impact of astaxanthin-enriched algal powder of Haematococcus pluvialis on memory improvement in BALB/c mice. Environ Geochem Health 29:483–489PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Key Laboratory of Nuclear Agriculture, Isotope Institute Co., LtdHenan Academy of SciencesZhengzhouPeople’s Republic of China
  2. 2.Key Laboratory of Nutrition and Safety of Ministry of Education, College of Food Engineering and BiotechnologyTianjin University of Science & TechnologyTianjinPeople’s Republic of China
  3. 3.State Key Laboratory of Animal NutritionChina Agricultural UniversityBeijingPeople’s Republic of China

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