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Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans

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Abstract

In this study, a novel quercetin derivative bearing a trifluoromethyl group was synthesized by the nucleophilic aromatic substitution reaction between rutin and 2-chloro-5-(trifluoromethyl)-1,3-dinitrobenzene in basic medium. This synthetic quercetin showed antifungal activity against Candida albicans cultures. The results indicated a remarkable increase in the biological activity of this compound as compared to rutin.

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Acknowledgments

The authors are grateful to the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) of Argentina for financial support. M.G.A. and E.N.D. are Scientific Members of CONICET. T.C.T. thanks CONICET for a research fellowship.

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Correspondence to Edgardo N. Durantini.

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Tempesti, T.C., Alvarez, M.G., de Araújo, M.F. et al. Antifungal activity of a novel quercetin derivative bearing a trifluoromethyl group on Candida albicans . Med Chem Res 21, 2217–2222 (2012). https://doi.org/10.1007/s00044-011-9750-x

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  • DOI: https://doi.org/10.1007/s00044-011-9750-x

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