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Synthesis and pharmacological evaluation of some new naphthol derived aryloxy derivatives as cognition enhancers

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Abstract

The present research was designed to describe the synthesis of a series of some 1-naphthol derivatives with their antiamnesic activity using mice as the animal model and piracetam as the reference drug. All the synthesized compounds were characterized by spectroscopic techniques, elemental analysis and were screened for their efficacy as cognition enhancers by elevated plus maze test and acetylcholinestrase inhibitory assay. Compound 7a was found to be the most potent in reversing the amnesia and in inhibiting the acetylcholinesterase.

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Acknowledgment

The authors are grateful to University Grants Commission, New Delhi, India for providing financial assistance to carry out this work.

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Authors and Affiliations

  1. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India

    Poonam Piplani, Ruchi Malik, Bhavneet Kaur & Anuradha Kaplish

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  1. Poonam Piplani
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  2. Ruchi Malik
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  3. Bhavneet Kaur
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  4. Anuradha Kaplish
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Correspondence to Poonam Piplani.

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Piplani, P., Malik, R., Kaur, B. et al. Synthesis and pharmacological evaluation of some new naphthol derived aryloxy derivatives as cognition enhancers. Med Chem Res 21, 1771–1779 (2012). https://doi.org/10.1007/s00044-011-9686-1

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  • DOI: https://doi.org/10.1007/s00044-011-9686-1

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