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Synthesis, spectroscopic, thermal and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine

Medicinal Chemistry Research volume 21, pages 1708–1716 (2012)Cite this article

Abstract

Coordination complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff base derived from syringaldehyde and 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine have been synthesized. These complexes have been characterized by elemental analysis, magnetic moment, spectroscopic (IR, Electronic, 1H NMR, ESR) and thermogravimetric analysis. Magnetic and spectral data suggest octahedral geometry for Co(II), Ni(II) and Zn(II) complexes and square planar for Cu(II) complexes. The presence of coordinated water in metal complexes was confirmed by thermal and IR data. The Schiff base and its metal complexes have been screened for antibacterial (Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, Staphylococcus aureus) and antifungal activities (Aspergillus niger, A. flavus). A comparison is made between activities of complexes with Schiff base and with the standard antibiotics.

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Acknowledgments

One of the authors Yogender Kumar is highly thankful to University Grant commission, New Delhi for providing junior research fellowship (JRF) and Department of Chemistry, Kurukshetra University Kurukshetra, for providing facilities to carry out this research work.

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Authors and Affiliations

  1. Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, India

    Kiran Singh, Yogender Kumar & Parvesh Puri

  2. Department of Microbiology, Kurukshetra University, Kurukshetra, 136119, India

    Chetan Sharma & K. R. Aneja

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  1. Kiran Singh
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  2. Yogender Kumar
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  3. Parvesh Puri
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  4. Chetan Sharma
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  5. K. R. Aneja
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Correspondence to Kiran Singh.

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Singh, K., Kumar, Y., Puri, P. et al. Synthesis, spectroscopic, thermal and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine. Med Chem Res 21, 1708–1716 (2012). https://doi.org/10.1007/s00044-011-9683-4

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Keywords

  • Schiff base
  • 1,2,4-triazine
  • Thermal studies
  • Antimicrobial activity
  • Octahedral complexes