Abstract
In this article, we have described the conventional and microwave method for the synthesis of 1-[2-(2-chloro(3-quinolyl))-5-(4-nitrophenyl)(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones (4a–l). Through this method, we have achieved reduction in reaction time and better yield than the previously described conventional method. The application of microwave irradiation (MWI) is used for carrying out chemical transformations which are pollution-free and eco-friendly. The structure of the compounds was characterized by spectral data. These compounds (4a–l) were evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi.
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Acknowledgments
The authors are thankful to Department of Chemistry, Bhavnagar University, Bhavnagar for providing research facilities. One of the authors AMD is thankful to University Grants Commission, New Delhi for providing UGC-meritorious fellowship.
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Desai, N.C., Dodiya, A.M. Conventional and microwave techniques for synthesis and antimicrobial studies of novel 1-[2-(2-chloro(3-quinolyl))-5-(4-nitrophenyl)-(1,3,4-oxadiazolin-3-yl)]-3-(aryl)prop-2-en-1-ones. Med Chem Res 21, 1480–1490 (2012). https://doi.org/10.1007/s00044-011-9670-9
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DOI: https://doi.org/10.1007/s00044-011-9670-9