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Photoisomerism of a vasodilator cinepazide maleate

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Abstract

The photoinduced tautomerisation of cinepazide maleate (1), an effective vasodilator widely used in clinical therapy, had been investigated. It was found that (i) the higher the concentration of cinepazide maleate (1), the more stable it was; (ii) the effect of light on the photoisomerism of cinepazide maleate (1) was obvious in a suitable wavelength (e.g., 365 nm); (iii) solvents (e.g., acetone) with carbonyl chromophore absorbing UV could inhibit the generation of cis-isomer; (iv) anthranilic acid could be used as an effective ultraviolet absorbent and (v) the cinepazide maleate (1) could be properly stored under the airtight, light-free and room temperature conditions.

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Acknowledgment

The authors thank the staff of Testing and Analysis Center of Dalian University of Technology for the spectral characterisation.

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Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116024, China

    Huaxiang Liu, Feifei Qi & Qingwei Meng

  2. Dalian Merro Pharmaceutical Factory, Dalian, 116025, China

    Yanan Hao & Shuxiang Dong

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  1. Huaxiang Liu
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  2. Feifei Qi
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  3. Yanan Hao
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  4. Shuxiang Dong
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  5. Qingwei Meng
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Correspondence to Qingwei Meng.

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Liu, H., Qi, F., Hao, Y. et al. Photoisomerism of a vasodilator cinepazide maleate. Med Chem Res 20, 1154–1157 (2011). https://doi.org/10.1007/s00044-010-9447-6

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  • DOI: https://doi.org/10.1007/s00044-010-9447-6

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