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Anti-inflammatory activity of 2,5-dihydroxycyclohepta-2,4,6-trienone in rats

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Abstract

In this study, the anti-inflammatory effects of a tropolone derivative, 2,5-dihydroxycyclohepta-2,4,6-trienone (AD-4), were investigated. The anti-inflammatory potency of AD-4 was compared with that of indomethacin in carrageenan-induced inflammation models in rats. The effect on vascular permeability was also determined by hyaluronidase-induced capillary permeability. AD-4 decreased carrageenan-induced paw edema at doses of 3.62 × 102, 7.24 × 102, and 14.48 × 102 μmol/kg by 45% (p < 0.001), 79% (p < 0.001), and 83% (p < 0.001), respectively, compared with the value of 49% (p < 0.001) for indomethacin (69.8 μmol/kg). Additionally, AD-4 decreased hyaluronidase-induced capillary permeability significantly. In conclusion, AD-4 was determined to have anti-inflammatory effects with lower toxicity than indomethacin. Anti-inflammatory effect of AD-4 may be related to its effects on vascular permeability.

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Acknowledgements

We would like to express our thanks to Prof. Dr. Metin BALCI and Prof. Dr. Arif DASTAN who synthesized AD-4 for their contribution to this work.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey

    Feride Koc

  2. Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, 25240, Turkey

    Elif Cadirci, Abdulmecit Albayrak, Zekai Halici, Ahmet Hacimuftuoglu & Halis Suleyman

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  1. Feride Koc
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  2. Elif Cadirci
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  3. Abdulmecit Albayrak
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  4. Zekai Halici
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  5. Ahmet Hacimuftuoglu
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  6. Halis Suleyman
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Correspondence to Halis Suleyman.

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Koc, F., Cadirci, E., Albayrak, A. et al. Anti-inflammatory activity of 2,5-dihydroxycyclohepta-2,4,6-trienone in rats. Med Chem Res 19, 84–93 (2010). https://doi.org/10.1007/s00044-009-9174-z

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