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Zinc-oxide-eugenol alters labeling of blood constituents with technetium-99m and shape of red blood cells

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Abstract

Samples of blood incubated with OZE, stannous chloride, and 99 mTc were isolated and fractions were separated. Radioactivity of the blood constituents decreased significantly (p < 0.05) due to the OZE. Morphological alterations were also found. Although rats were utilized in these experiments, precaution is recommended in the interpretation of nuclear-medicine examinations in patients that have been treated with OZE in dentistry procedures.

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Acknowledgements

Financial support: CNPq, CAPES, FAPERJ

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Authors and Affiliations

  1. Faculdade de Odontologia de Nova Friburgo, Nova Friburgo, Rio de Janeiro, Brazil

    Severo de Paoli

  2. Laboratório de Radiofarmácia Experimental, Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87 Vila Isabel, 20551-030, Rio de Janeiro, Brazil

    Severo de Paoli

  3. Faculdade de Fisioterapia, Universidade Estácio de Sá, Rio de Janeiro, Brazil

    Tania Santos Giani

  4. Departamento de Ciências Fisiológicas, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

    Giuseppe Antonio Presta

  5. Centro Universitário Serra dos Órgãos, Teresopolis, RJ, Brazil

    Carlos Guilherme Correa

  6. Setor de Fisioterapia, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

    Adalgisa Ieda Maiworm

  7. Departamento de Ciências Biomédicas, Centro Universitário de Volta Redonda, Volta Redonda, RJ, Brazil

    Sebastião David Santos-Filho

  8. Instituto Roberto Alcantara Gomes, Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    Mario Bernardo-Filho

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  1. Severo de Paoli
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  2. Tania Santos Giani
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  3. Giuseppe Antonio Presta
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  4. Carlos Guilherme Correa
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  5. Adalgisa Ieda Maiworm
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  6. Sebastião David Santos-Filho
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  7. Mario Bernardo-Filho
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Correspondence to Severo de Paoli.

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de Paoli, S., Giani, T.S., Presta, G.A. et al. Zinc-oxide-eugenol alters labeling of blood constituents with technetium-99m and shape of red blood cells. Med Chem Res 18, 373–382 (2009). https://doi.org/10.1007/s00044-008-9134-z

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  • DOI: https://doi.org/10.1007/s00044-008-9134-z

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