Abstract
A collection of biolabile (E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones 8–13 are synthesized, characterized by melting point, elemental analysis, mass spectroscopy (MS), Fourier-transform infrared (FT-IR), and 1H and 13C nuclear magnetic resonance (NMR) spectroscopic data and evaluated for their in vitro antibacterial and antifungal activities. Compounds 8–13 exerted a wide range of antibacterial activities against all tested Gram-positive and Gram-negative bacterial strains. All the compounds 8–13 were more active against Pseudomonas. Of the synthesized compounds, compounds 9 and 11 exhibited a wide range of antibacterial activities against Staphylococcus aureus, β-Heamolytic streptococcus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas. Compounds 10, 12, and 13 exerted strong antifungal activities against all tested fungal strains, namely Aspergillus flavus, Mucor, Rhizopus, and Microsporum gypsuem.
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Acknowledgements
The authors would like to thank the NMR Research Centre, Indian Institute of Science, Bangalore for recording spectra. Two of the authors, namely J. Thanusu and V. Kanagarajan, would like to thank the Annamalai University authorities for providing financial support in the form of Research Fellowship.
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Gopalakrishnan, M., Thanusu, J., Kanagarajan, V. et al. Synthesis, antibacterial, and antifungal activities of biolabile (E)-1-(4-morpholinophenyl)-3-aryl-prop-2-en-1-ones. Med Chem Res 18, 341–350 (2009). https://doi.org/10.1007/s00044-008-9131-2
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DOI: https://doi.org/10.1007/s00044-008-9131-2