Abstract
In this study, the effects of nimesulide on the antiinflammatory and ulcerative action of some nonsteroidal antiinflammatory drugs (NSAIDs; (diclofenac sodium, ibuprofen, meloxicam) were investigated in rats, and it was determined whether nimesulide interacts with these drugs in vivo and in vitro. Results showed that while diclofenac sodium, ibuprofen, and meloxicam reduced carrageenan-induced paw edema in rats by 66%, 39.6%, and 58%, respectively, when used alone, they reduced carrageenan-induced paw edema by 69.8%, 56.6%, and 66%, respectively, when combined with nimesulide. Diclofenac (25 mg kg-1) and meloxicam (7.5 mg kg-1) produced 9.3 and 19.6 mm2 ulcer areas in stomachs of rats, respectively, when used alone, but when combined with nimesulide diclofenac and meloxicam did not cause any injury in rat stomachs. While ranitidine at 100 mg kg-1 dose prevented diclofenac-induced ulcer formation, it reduced meloxicam-induced ulcer formation significantly. We conclude that nimesulide does not interact with these drugs in terms of antiinflammatory action and antagonizes their side effects on gastric tissue without reacting chemically.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
al-Tuwaijri AS, Mustafa AA (1992) Verapamil enhances the inhibitory effect of diclofenac on the chemiluminescence of human polymorphonuclear leukocytes and carrageenan-induced rat’s paw oedema. Int J Immunopharmacol 14:83–91
Burke A, Smyth E, Fitzgerald GA (2006) Analgesic-antipyretic agents; Pharmacotherapy of gout. In: Brunton L (ed), Godman and Gilman’s The Pharmacological Basis of Therapeutics. New-York: Mc Graw-Hill, pp 671–717
Cullen L, Kelly L, Connors D, Fitzgerald DJ (1988) Selective COX-2 inhibition by nimesulide in man. J Pharmacol Exp Ther 287:578–582
Demircan B, Celik D, Suleyman H, Akcay F (2005) Effect of indomethacin celecoxib and meloxicam on glutathione, malondialdehyde and myeloperoxidase in rat gastric tissue. The Pain Clinic 17:383–388
Gamache DA, Povlishock JT, Ellis EF (1986) Carrageenan-induced brain inflammation. Characterization of the model. J Neurosurg 65:679–685
Marzocco S, Di Paola R, Serraino I, Sorrentino R, Meli R, Mattaceraso G,Cuzzocrea S, Pinto A, Autore G (2004) Effect of methylguanidine in carrageenan-induced acute inflammation in the rats. Eur J Pharmacol 484:341–350
Patrignani P (2000) Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer. Toxicol Lett 112–113:493–498
Ramprasath VR, Shanthi P, Sachdanandam P (2004) Anti-inflammatory effect of Semecarpus anacardium Linn. Nut extract in acute and chronic inflammatory conditions. Biol Pharm Bull 27:2028–2031
Schattenkirchner M (1997) Meloxicam: a selective COX-2 inhibitor non-steroidal anti-inflammatory drug. Expert Opin Invest Drugs 6:321–334
Simon LS, Weaver AL, Graham DY, Kivitz AJ, Lipsky PE, Hubbard RC, Isakson PC, Verburg KM, Yu SS, Zhao WW, Geis GS (1999) Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA 282:1921–1928
Suleyman H, Akcay F, Altinkaynak K (2002a) The effect of nimesulide on the indomethacin- and ethanol-induced gastric ulcer in rats. Pharmacol Res 45:155–158
Suleyman H, Altinkaynak K, Gocer F, Maras A, Akcay F, Onuk MD, Gepdiremen A (2002b) Effect of nimesulide on the indomethacin- and ibuprofen-induced ulcer in rat gastric tissue. Pol J Pharmacol 54:255–259
Suleyman H, Demircan B, Karagoz Y, Oztasan N, Suleyman B (2004) Anti-inflammatory effects of selective COX-2 inhibitors. Pol J Pharmacol 56:775–780
Suleyman H, Demirezer LO, Kuruuzum-Uz A (2004) Effects of Rumex patientia root extract on indomethacin and ethanol induced gastric damage in rats. Pharmazie 59:147–149
Suleyman H, Demirezer LO, Kuruuzum-Uz A, Akcay F (2002c) Gastroprotective and antiulcerogenic effects of Rumex patientia L. extract. Pharmazie 57:204–205
Tegeder I, Neupert W, Guhring H, Geisslinger G (2000) Effects of selective and unselective cyclooxygenase inhibitors on prostanoid release from various rat organs. J Pharmacol Exp Ther 292:1161–1168
Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96:7563–7568
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Suleyman, H., Salamci, E., Cadirci, E. et al. Beneficial interaction of nimesulide with NSAIDs. Med Chem Res 16, 78–87 (2007). https://doi.org/10.1007/s00044-007-9009-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00044-007-9009-8