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Design, synthesis, and in vitro evaluation of cytotoxic activity of new substituted 1,4-benzoquinones and hydroquinones

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Abstract

A new series of p-benzoquinones, hydroquinones, and quinol dimethyl ethers substituted by a pyrazole ring either directly or after an oxoethyl linker was synthesized and screened for in vitro cytotoxic activity. Compounds 8d, f, g, i, and 9c, f, and 13c exhibited broad-spectrum activity (GI50 MG-MID values 9.27–14.72 μM). With regard to sensitivity, compounds 8f and 9c, f have proved to possess a remarkable activity against leukemia tumor cell lines (GI50 = 3.43–5.03 μM). Indeed, compound 13c showed the highest activity profile against individual leukemia subpanel cell line SR (GI50 = 0.91 μM).

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, 21215, Egypt

    Ibrahim Chaaban, El-Sayeda EL-Khawass, Mona Mahran, Ola El-Sayed & Hassan El-Saidi

  2. Biological and Medical Research Department, MBC-03 King Faisal Specialist Hospital and Research Center, Rhyiad, Saudi Arabia

    Hassan Aboul-Enen

Authors
  1. Ibrahim Chaaban
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  2. El-Sayeda EL-Khawass
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  3. Mona Mahran
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  4. Ola El-Sayed
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  5. Hassan El-Saidi
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  6. Hassan Aboul-Enen
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Correspondence to Mona Mahran.

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Chaaban, I., EL-Khawass, ES., Mahran, M. et al. Design, synthesis, and in vitro evaluation of cytotoxic activity of new substituted 1,4-benzoquinones and hydroquinones. Med Chem Res 16, 49–77 (2007). https://doi.org/10.1007/s00044-007-9001-3

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  • DOI: https://doi.org/10.1007/s00044-007-9001-3

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