Abstract
Objectives
Long working hours have been associated with cardiovascular disease (CVD) mortality. However, results are inconsistent and large cohort studies are needed to confirm these findings.
Methods
We conducted a census-based cohort study including 11,903,540 Italian workers aged 20–64 years, registered in the 2011 census, with a 5-year follow-up (2012–2016). We estimated cause-specific hazard ratios (cHRs) through Cox regression models to quantify the association between long working hours and CVD mortality.
Results
Over 5 years of follow-up, 17,206 individuals died from CVD (15,262 men and 1944 women). Men working 55 or more hours per week had a cHR of 0.95 (95% confidence interval, CI 0.89–1.02) for all CVDs, while women showed a cHR of 1.19 (95% CI 0.95–1.49). Professional women working more than 55 h per week had a cHR of 1.98 (95% CI 0.87–4.52).
Conclusions
This study does not support an association between long working hours and CVD mortality among active Italian men, while it suggests a possible excess risk among women, although based on limited number of events.
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References
Alicandro G, Frova L, Sebastiani G, El Sayed I, Boffetta P, La Vecchia C (2017) Educational inequality in cancer mortality: a record linkage study of over 35 million Italians. Cancer Causes Control 28:997–1006. https://doi.org/10.1007/s10552-017-0930-y
Chandola T, Brunner E, Marmot M (2006) Chronic stress at work and the metabolic syndrome: prospective study. BMJ 332:521–525. https://doi.org/10.1136/bmj.38693.435301.80
Chandola T, Britton A, Brunner E et al (2008) Work stress and coronary heart disease: what are the mechanisms? Eur Heart J 29:640–648. https://doi.org/10.1093/eurheartj/ehm584
Dixon JP, Dixon JK, Spinner JC (1991) Tensions between career and interpersonal commitments as a risk factor for cardiovascular disease among women. Women Health 17:33–57. https://doi.org/10.1300/J013v17n03_03
Doll R, Smith PG, Waterhouse JAH, et al (1982) Comparison between registries: age-standardized rates. Vol. IV. IARC Sci Publ No. 42. In: Cancer incidence in five continents, pp 671–675
Durazo EM, de Baca TC, Slopen N et al (2018) Parity, Job Strain, and Cardiovascular Risk in the Women’s Health Study. Curr Cardiovasc Risk 12:8. https://doi.org/10.1007/s12170-018-0571-z
Grosch JW, Caruso CC, Rosa RR, Sauter SL (2006) Long hours of work in the U.S.: associations with demographic and organizational characteristics, psychosocial working conditions, and health. Am J Ind Med 49:943–952. https://doi.org/10.1002/ajim.20388
Hannerz H, Soll-Johanning H (2018) Working hours and all-cause mortality in relation to the EU Working Time Directive: a Danish cohort study. Eur J Public Health 28:810–814. https://doi.org/10.1093/eurpub/cky027
Hannerz H, Albertsen K, Burr H et al (2018a) Long working hours and stroke among employees in the general workforce of Denmark. Scand J Public Health 46:368–374. https://doi.org/10.1177/1403494817748264
Hannerz H, Larsen AD, Garde AH (2018b) Long weekly working hours and ischaemic heart disease: a follow-up study among 145 861 randomly selected workers in Denmark. BMJ Open 8:e019807. https://doi.org/10.1136/bmjopen-2017-019807
Holtermann A, Mortensen OS, Burr H, Sogaard K, Gyntelberg F, Suadicani P (2010) Long work hours and physical fitness: 30-year risk of ischaemic heart disease and all-cause mortality among middle-aged Caucasian men. Heart 96:1638–1644. https://doi.org/10.1136/hrt.2010.197145
Kivimaki M, Kawachi I (2015) Work Stress as a Risk Factor for Cardiovascular Disease. Curr Cardiol Rep 17:630. https://doi.org/10.1007/s11886-015-0630-8
Kivimaki M, Jokela M, Nyberg ST et al (2015a) Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals. Lancet 386:1739–1746. https://doi.org/10.1016/S0140-6736(15)60295-1
Kivimaki M, Singh-Manoux A, Nyberg S, Jokela M, Virtanen M (2015b) Job strain and risk of obesity: systematic review and meta-analysis of cohort studies. Int J Obes (Lond) 39:1597–1600. https://doi.org/10.1038/ijo.2015.103
Kivimaki M, Nyberg ST, Batty GD et al (2017) Long working hours as a risk factor for atrial fibrillation: a multi-cohort study. Eur Heart J 38:2621–2628. https://doi.org/10.1093/eurheartj/ehx324
Kunz-Ebrecht SR, Kirschbaum C, Marmot M, Steptoe A (2004) Differences in cortisol awakening response on work days and weekends in women and men from the Whitehall II cohort. Psychoneuroendocrinology 29:516–528
Lindeberg SI, Rosvall M, Choi B et al (2011) Psychosocial working conditions and exhaustion in a working population sample of Swedish middle-aged men and women. Eur J Public Health 21:190–196. https://doi.org/10.1093/eurpub/ckq039
Low CA, Thurston RC, Matthews KA (2010) Psychosocial factors in the development of heart disease in women: current research and future directions. Psychosom Med 72:842–854. https://doi.org/10.1097/PSY.0b013e3181f6934f
Ness RB, Harris T, Cobb J et al (1993) Number of pregnancies and the subsequent risk of cardiovascular disease. N Engl J Med 328:1528–1533. https://doi.org/10.1056/NEJM199305273282104
Nyberg ST, Fransson EI, Heikkila K et al (2013) Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women. PLoS ONE 8:e67323. https://doi.org/10.1371/journal.pone.0067323
O’Reilly D, Rosato M (2013) Worked to death? A census-based longitudinal study of the relationship between the numbers of hours spent working and mortality risk. Int J Epidemiol 42:1820–1830. https://doi.org/10.1093/ije/dyt211
Radi S, Lang T, Lauwers-Cances V et al (2005) Job constraints and arterial hypertension: different effects in men and women: the IHPAF II case control study. Occup Environ Med 62:711–717. https://doi.org/10.1136/oem.2004.012955
Rosvall M, Ostergren PO, Hedblad B, Isacsson SO, Janzon L, Berglund G (2002) Work-related psychosocial factors and carotid atherosclerosis. Int J Epidemiol 31:1169–1178. https://doi.org/10.1093/ije/31.6.1169
Schiebinger L (2014) Scientific research must take gender into account. Nature 507:9. https://doi.org/10.1038/507009a
Slopen N, Glynn RJ, Buring JE, Lewis TT, Williams DR, Albert MA (2012) Job strain, job insecurity, and incident cardiovascular disease in the Women’s Health Study: results from a 10-year prospective study. PLoS ONE 7:e40512. https://doi.org/10.1371/journal.pone.0040512
Steptoe A, Kivimaki M (2013) Stress and cardiovascular disease: an update on current knowledge. Annu Rev Public Health 34:337–354. https://doi.org/10.1146/annurev-publhealth-031912-114452
Virtanen M, Ferrie JE, Singh-Manoux A et al (2010) Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study. Eur Heart J 31:1737–1744. https://doi.org/10.1093/eurheartj/ehq124
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GA, LF and PB conceived the study. GA and PB performed the data analysis and drafted the manuscript. All authors contributed to the interpretation of the results.
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This study is part of an extensive project of the Italian National Institute of Statistics based on the record linkage of pre-existing data. Data were anonymized and irreversibly de-identified after the linkage. The project is included in the National Statistical Program and was approved by the Italian Data Protection Authority.
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Alicandro, G., Bertuccio, P., Sebastiani, G. et al. Long working hours and cardiovascular mortality: a census-based cohort study. Int J Public Health 65, 257–266 (2020). https://doi.org/10.1007/s00038-020-01361-y
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DOI: https://doi.org/10.1007/s00038-020-01361-y