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Diabetes mellitus and treatment outcomes of pulmonary tuberculosis: a cohort study



This study aimed to investigate the impact of diabetes on the treatment outcomes among pulmonary TB patients in Yerevan, Armenia.


We utilized a cohort study design that included TB patients with diabetes and TB patients without diabetes. The data collection was conducted in the National Tuberculosis Control Center, eight tuberculosis outpatient centers and the ‘Prisoners’ Hospital’ in Yerevan, Armenia. Data were collected from an existing national TB database and patients medical records. Multivariable logistic regressions were conducted to construct the final model and test the associations.


The final sample included 621 patients 5.8% of whom had diabetes. The odds of having treatment failure was 8.99 times higher among TB patients with diabetes (95% confidence interval 2.51–32.23) compared to TB patients without diabetes after adjusting for weight and sputum smear status.


Diabetes comorbidity had a negative effect on TB treatment outcomes. Countries with a high burden of both TB and diabetes need to develop mechanisms for active screening for diabetes among patients with TB and address their treatment needs carefully.

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This project could not have been accomplished without the support of the National TB Control Center of Armenia. We would like to thank specially NTCC director Dr. Armen Hayrapetyan, Drs. Karapet Davtyan and Hayk Davtyan as well as all TB health care providers for their cooperation during the data collection period.

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Authors and Affiliations



SS, VP and LA designed the study; SS collected and analyzed the data and drafted the manuscript; VP and LA contributed to the development of the manuscript. All authors contributed toward finalizing the manuscript and approved the final version for submission.

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Correspondence to Serine Sahakyan.

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The authors declare that they have no conflict of interests.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Considering the nature of the study (secondary data analysis), the requirement of the informed consent was waived.

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Minor Revision: 15 February 2019.

Major Revision: 05 June 2019.

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Sahakyan, S., Petrosyan, V. & Abrahamyan, L. Diabetes mellitus and treatment outcomes of pulmonary tuberculosis: a cohort study. Int J Public Health 65, 37–43 (2020).

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  • Treatment failure
  • Cohort study
  • Tuberculosis
  • Diabetes