International Journal of Public Health

, Volume 58, Issue 5, pp 757–764 | Cite as

The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life

  • Lidia Casas
  • Jan Paul Zock
  • Anne Elie Carsin
  • Ana Fernandez-Somoano
  • Ana Esplugues
  • Loreto Santa-Marina
  • Adonina Tardón
  • Ferran Ballester
  • Mikel Basterrechea
  • Jordi Sunyer
Original Article

Abstract

Objective

To evaluate the effects of household use of cleaning products during pregnancy on infant wheezing and lower respiratory tract infections (LRTI).

Methods

In four prospective Spanish birth cohorts (n = 2,292), pregnant women reported the use of household cleaning products. When infants were 12–18 months old, current cleaning product use and infant’s wheezing and LRTI were reported. Cohort-specific associations between the use of specific products and respiratory outcomes were evaluated using multivariable regression analyses and estimates were combined using random-effects meta-analyses.

Results

The period prevalence of LRTI was higher when sprays (combined odds ratio (OR) = 1.29; 95 % confidence interval (CI) 1.04–1.59) or air fresheners (OR = 1.29; CI 1.03–1.63) were used during pregnancy. The odds of wheezing increased with spray (OR = 1.37; CI 1.10–1.69) and solvent (OR = 1.30; CI 1.03–1.62) use. The associations between spray and air freshener use during pregnancy and both outcomes remained apparent when these products were not used after pregnancy. Nevertheless, the estimates were higher when post-natal exposure was included.

Conclusion

The use of cleaning sprays, air fresheners and solvents during pregnancy may increase the risk of wheezing and infections in the offspring.

Keywords

Household products Respiratory tract infections Wheezing Infant Longitudinal studies 

Supplementary material

38_2012_417_MOESM1_ESM.doc (182 kb)
Supplementary material 1 (DOC 182 kb)

References

  1. Dietert RR, Zelikoff JT (2008) Early-life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma. Birth Defects Res B Dev Reprod Toxicol 83:547–560. doi:10.1002/bdrb.20170 PubMedCrossRefGoogle Scholar
  2. Farrow A, Taylor H, Northstone K, Golding J (2003) Symptoms of mothers and infants related to total volatile organic compounds in household products. Arch Environ Health 58:633–641. doi:10.3200/AEOH.58.10.633-641 PubMedCrossRefGoogle Scholar
  3. Henderson J, Sherriff A, Farrow A, Ayres JG (2008) Household chemicals, persistent wheezing and lung function: effect modification by atopy? Eur Respir J 31:547–554. doi:10.1183/09031936.00086807 PubMedCrossRefGoogle Scholar
  4. Herr M, Just J, Nikasinovic L et al (2012) Influence of host and environmental factors on wheezing severity in infants: findings from the PARIS birth cohort. Clin Exp Allergy 42:275–283. doi:10.1111/j.1365-2222.2011.03933.x PubMedCrossRefGoogle Scholar
  5. Jaakkola JJK, Jaakkola MS (2006) Professional cleaning and asthma. Curr Opin Allergy Clin Immunol 6:85–90. doi:10.1097/01.all.0000216849.64828.55 PubMedCrossRefGoogle Scholar
  6. Karr C, Lumley T, Shepherd K et al (2006) A case-crossover study of wintertime ambient air pollution and infant bronchiolitis. Environ Health Perspect 114:277–281PubMedCrossRefGoogle Scholar
  7. Kogevinas M, Antó JM, Sunyer J et al (1999) Occupational asthma in Europe and other industrialised areas: a population-based study. European Community Respiratory Health Survey Study Group. Lancet 353:1750–1754PubMedCrossRefGoogle Scholar
  8. Medina-Ramón M, Zock JP, Kogevinas M et al (2003) Asthma symptoms in women employed in domestic cleaning: a community based study. Thorax 58:950–954PubMedCrossRefGoogle Scholar
  9. Medina-Ramón M, Zock JP, Kogevinas M et al (2005) Asthma, chronic bronchitis, and exposure to irritant agents in occupational domestic cleaning: a nested case–control study. Occup Environ Med 62:598–606. doi:10.1136/oem.2004.017640 PubMedCrossRefGoogle Scholar
  10. Medina-Ramón M, Zock JP, Kogevinas M et al (2006) Short-term respiratory effects of cleaning exposures in female domestic cleaners. Eur Respir J 27:1196–1203. doi:10.1183/09031936.06.00085405 PubMedCrossRefGoogle Scholar
  11. Nickmilder M, Carbonnelle S, Bernard A (2007) House cleaning with chlorine bleach and the risks of allergic and respiratory diseases in children. Pediatr Allergy Immunol 18:27–35. doi:10.1111/j.1399-3038.2006.00487.x PubMedCrossRefGoogle Scholar
  12. Ribas-Fitó N, Ramón R, Ballester F et al (2006) Child health and the environment: the INMA Spanish Study. Paediatr Perinat Epidemiol 20:403–410. doi:10.1111/j.1365-3016.2006.00745.x PubMedCrossRefGoogle Scholar
  13. Ségala C, Poizeau D, Mesbah M et al (2008) Winter air pollution and infant bronchiolitis in Paris. Environ Res 106:96–100. doi:10.1016/j.envres.2007.05.003 PubMedCrossRefGoogle Scholar
  14. Sherriff A, Farrow A, Golding J, Henderson J (2005) Frequent use of chemical household products is associated with persistent wheezing in pre-school age children. Thorax 60:45–49. doi:10.1136/thx.2004.021154 PubMedCrossRefGoogle Scholar
  15. Sigurs N, Aljassim F, Kjellman B et al (2010) Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 65:1045–1052. doi:10.1136/thx.2009.121582 PubMedCrossRefGoogle Scholar
  16. Smith KR, Samet JM, Romieu I, Bruce N (2000) Indoor air pollution in developing countries and acute lower respiratory infections in children. Thorax 55:518–532PubMedCrossRefGoogle Scholar
  17. Sunyer J, Garcia-Esteban R, Alvarez M et al (2010) DDE in mothers’ blood during pregnancy and lower respiratory tract infections in their infants. Epidemiology 21:729–735. doi:10.1097/EDE.0b013e3181e5ea96 PubMedCrossRefGoogle Scholar
  18. Zock J-P, Plana E, Jarvis D et al (2007) The use of household cleaning sprays and adult asthma: an international longitudinal study. Am J Respir Crit Care Med 176:735–741. doi:10.1164/rccm.200612-1793OC PubMedCrossRefGoogle Scholar
  19. Zock J-P, Plana E, Antó JM et al (2009) Domestic use of hypochlorite bleach, atopic sensitization, and respiratory symptoms in adults. J Allergy Clin Immunol 124(731–738):e1. doi:10.1016/j.jaci.2009.06.007 PubMedGoogle Scholar
  20. Zock J-P, Vizcaya D, Le Moual N (2010) Update on asthma and cleaners. Curr Opin Allergy Clin Immunol 10:114–120. doi:10.1097/ACI.0b013e32833733fe PubMedCrossRefGoogle Scholar

Copyright information

© Swiss School of Public Health 2012

Authors and Affiliations

  • Lidia Casas
    • 1
    • 2
    • 3
  • Jan Paul Zock
    • 1
    • 2
    • 3
  • Anne Elie Carsin
    • 1
    • 2
    • 3
  • Ana Fernandez-Somoano
    • 3
    • 4
  • Ana Esplugues
    • 3
    • 5
  • Loreto Santa-Marina
    • 3
    • 6
    • 7
  • Adonina Tardón
    • 3
    • 4
  • Ferran Ballester
    • 3
    • 5
    • 8
  • Mikel Basterrechea
    • 3
    • 6
    • 7
  • Jordi Sunyer
    • 1
    • 2
    • 3
    • 9
  1. 1.Centre for Research in Environmental Epidemiology (CREAL)BarcelonaSpain
  2. 2.Hospital del Mar Research Institute (IMIM)BarcelonaSpain
  3. 3.CIBER Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain
  4. 4.University of OviedoOviedoSpain
  5. 5.Center for Public Health Research-CSISPValenciaSpain
  6. 6.Subdirección de Salud Pública de Gipuzkoa, Departamento de Sanidad, Gobierno VascoSan SebastiánSpain
  7. 7.Instituto de Investigación Sanitaria BiodonostiaSan SebastiánSpain
  8. 8.University of ValenciaValenciaSpain
  9. 9.Pompeu Fabra UniversityBarcelonaSpain

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