A model for bone mechanics and remodeling including cell populations dynamics


In this paper, we propose a model for the description of bone mechanics and bone remodeling processes, including bone cell populations dynamics. The latter, described by a system of ODEs, influences the values for the elastic parameters used in the mechanical model, which in turn determines the “stimulus” function affecting the behavior of the cells. Numerical simulations concerning the behavior of the bone under external loads, as well as simple fracture healing processes are presented. The model can reproduce the qualitative behavior of bone tissue remodeling and mechanical response.

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Correspondence to Fabio Di Cosmo.

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Rapisarda, A.C., Della Corte, A., Drobnicki, R. et al. A model for bone mechanics and remodeling including cell populations dynamics. Z. Angew. Math. Phys. 70, 9 (2019). https://doi.org/10.1007/s00033-018-1055-1

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  • Bone tissue
  • Bone remodeling
  • Cell populations dynamics
  • Numerical simulations of bone mechanics

Mathematics Subject Classification

  • 74F99
  • 74B99