Abstract
Synaptic target recognition is a complex molecular event. In a differentiating presynaptic terminal, relatively ‘rare’ molecules first detect the cell identity of the synaptic target. Subsequently, many ‘common’ molecules continue the process of synaptogenesis. We present a theoretical framework for understanding synaptic target recognition and discuss the features of its molecular components and their integration, drawing on the rapid progress made in recent studies.
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Hoang, B., Chiba, A. ‘Identify’ and ‘lock in’: molecular integration during synaptic target recognition. CMLS, Cell. Mol. Life Sci. 55, 1399–1406 (1999). https://doi.org/10.1007/s000180050380
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DOI: https://doi.org/10.1007/s000180050380