Abstract
Centrally given interleukin (IL)-1 is known to induce a rapid rises in blood IL-6. To extend this and to examine the mechanism by which this occurs, the effects of intracerebroventricular (icv) injection of human recombinant IL-1β on mRNA expression of IL-6 and tumour necrosis factor (TNF) in the spleen and liver were examined in rats. Icv injection of IL-1 produced a rapid rise of the tissue mRNA levels of IL-6 and TNF in both organs, prior to and/or in parallel with an increase in their serum levels. Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the IL-6 responses, while it had little influence on the TNF responses. The results suggest that brain IL-1 induces peripheral production of IL-6, but not of TNF, through autonomic nervous system activation.
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Received 27 October 1997; received after revision 15 December 1997; accepted 12 January 1998
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Kitamura, H., Okamoto, S., Shimamoto, Y. et al. Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis. CMLS, Cell. Mol. Life Sci. 54, 282–287 (1998). https://doi.org/10.1007/s000180050151
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DOI: https://doi.org/10.1007/s000180050151