Abstract
Metabolites isolated from marine invertebrates, callipeltin A 1, crambescidin 2, ptilomycalin A 3, celeromycalin 4, gymnochrome B 5, gymnochrome D 6 and isogymnochrome D 7 previously shown bioactive on either herpes simplex virus 1 (2, 3, 4) or human immunodeficiency virus (1, 5, 6, 7), were tested on a new in vitro bioassay using the dengue virus 1. Only gymnochrome D and isogymnochrome D isolated from the living fossil crinoid Gymnocrinus richeri are highly potent dengue antiviral agents.
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Received 22 August 1997; received after revision 6 November 1997; accepted 24 November 1997
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Laille, M., Gerald, F. & Debitus, C. In vitro antiviral activity on dengue virus of marine natural products. CMLS, Cell. Mol. Life Sci. 54, 167–170 (1998). https://doi.org/10.1007/s000180050138
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DOI: https://doi.org/10.1007/s000180050138