Abstract.
The effects of some noradrenergic agents, phenobarbitone, diazepam and phenytoin on seizures produced by propranolol were investigated in mice. Isoprenaline and DL-threo-3,4-dihydroxyphenylserine (DOPS) effectively antagonized the seizures elicited by propranolol. Pargyline and imipramine significantly attenuated propranolol-induced seizures and also significantly potentiated the protecting effect of DOPS against the seizures. α-Methyl-p-tyrosine, disulfiram and reserpine significantly potentiated propranolol-elicited seizures. However, DOPS significantly antagonized the seizure-potentiating effects of α-methyl-p-tyrosine, disulfiram and reserpine. Phenylephrine, clonidine, prazosin, idazoxan, phenobarbitone, diazepam and phenytoin did not significantly alter propranolol-induced seizures. These results suggest that propranolol-induced seizures in mice may involve a noradrenergic mechanism mediated via central β-adrenoceptors.
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Received 27 January 1997; received after revision 8 April 1997; accepted 29 April 1997
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Amabeoku, G., Syce, J. Propranolol-induced seizures in mice: the role of noradrenaline. CMLS, Cell. mol. life Sci. 53, 646–651 (1997). https://doi.org/10.1007/s000180050083
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DOI: https://doi.org/10.1007/s000180050083