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Biotransformation of the flavonoid tiliroside to 7-methylether tiliroside: bioactivity of this metabolite and of its acetylated derivative

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Abstract.

Incubation of kaempferol-3-O-β-D-(6"-E-p-coumaroyl)-glucopyranoside (tiliroside) (1) with Aspergillus nidulans gives the 7-methyl ether of tiliroside (2) which is a new compound. Its structure is determined by spectroscopic methods. Cytotoxic studies of 2 and of its acetylated derivative 2a were carried out in vitro against fourteen human leukemic cell lines. Results clearly show that compound 2 is ineffective against all leukemic cell lines tested. On the contrary, compound 2a exhibited cytotoxic activity against four of the cell lines (HL60, DAUDI, HUT78 and MOLT3) and additionally, a dose- and time-dependent effect on DNA synthesis.

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Authors and Affiliations

  1. Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, GR-157 71 Athens (Greece), Greece

    C. Demetzos & P. Magiatis

  2. Division of Genetics and Biotechnology, GR-157 01 Athens (Greece), e-mail: cdemetzo@atlas.uoa.gr, Greece

    M. A. Typas

  3. Hellenic Anticancer Institute, Department of Immunology, 171 Alexandras Ave., GR-115 22 Athens (Greece), Greece

    K. Dimas, R. Sotiriadou, S. Perez & D. Kokkinopoulos

Authors
  1. C. Demetzos
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  2. P. Magiatis
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  3. M. A. Typas
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  4. K. Dimas
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  5. R. Sotiriadou
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  6. S. Perez
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  7. D. Kokkinopoulos
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Additional information

Received 18 February 1997; received after revision 8 April 1997; accepted 6 May 1997

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Demetzos, C., Magiatis, P., Typas, M. et al. Biotransformation of the flavonoid tiliroside to 7-methylether tiliroside: bioactivity of this metabolite and of its acetylated derivative. CMLS, Cell. mol. life sci. 53, 587–592 (1997). https://doi.org/10.1007/s000180050076

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  • DOI: https://doi.org/10.1007/s000180050076

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