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Why are neuromelanin-containing dopaminergic neurons lost in idiopathic Parkinson’s disease?

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References

  1. Gao X, Huang Z, Feng C, Guan C, Li R, Xie H, Chen J, Li M, Que R, Deng B, Cao P, Li M, Lu J, Huang Y, Li M, Yang W, Yang X, Wen C, Liang X, Yang Q, Chao YX, Chan LL, Yenari MA, Jin K, Chaudhuri KR, Zhang J, Tan EK, Wang Q (2021) Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson's disease. Brief Bioinform 22(4):bbaa244. https://doi.org/10.1093/bib/bbaa244. (PMID: 33079984).

  2. Liang CL, Nelson O, Yazdani U, Pasbakhsh P, German DC (2004) Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. J Comp Neurol 473:97–106. https://doi.org/10.1002/cne.20098. (PMID: 15067721)

    Article  CAS  PubMed  Google Scholar 

  3. Wang Q, Zheng J, Pettersson S, Reynolds R, Tan EK (2023) The link between neuroinflammation and the neurovascular unit in synucleinopathies. Sci Adv. 9(7):eabq1141. https://doi.org/10.1126/sciadv.abq1141. (Epub 2023 Feb 15. PMID: 36791205; PMCID: PMC9931221)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Leggio L, Paternò G, Vivarelli S, Falzone GG, Giachino C, Marchetti B, Iraci N (2021) Extracellular vesicles as novel diagnostic and prognostic biomarkers for Parkinson’s disease. Aging Dis 12(6):1494–1515. https://doi.org/10.14336/AD.2021.0527. (PMID:34527424; PMCID:PMC8407885)

    Article  PubMed  PubMed Central  Google Scholar 

  5. Segura-Aguilar J, Mannervik B, Inzunza J, Varshney M, Nalvarte I, Muñoz P (2022) Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity. Neural Regen Res 17:1861–1866. https://doi.org/10.4103/1673-5374.335690. (PMID:35142659; PMCID:PMC8848618)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Wang S, Wu T, Cai Y, Yu Y, Chen X, Wang L (2023) Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson’s disease with freezing of gait. Front Aging Neurosci 2(15):1060935. https://doi.org/10.3389/fnagi.2023.1060935. (PMID:36819729; PMCID:PMC9932285)

    Article  CAS  Google Scholar 

  7. Isaias IU, Trujillo P, Summers P, Marotta G, Mainardi L, Pezzoli G, Zecca L, Costa A (2016) Neuromelanin imaging and dopaminergic loss in Parkinson’s disease. Front Aging Neurosci 22(8):196. https://doi.org/10.3389/fnagi.2016.00196. (PMID:27597825; PMCID:PMC4992725)

    Article  Google Scholar 

  8. Segura-Aguilar J, Muñoz P, Inzunza J, Varshney M, Nalvarte I, Mannervik B (2022) Neuroprotection against aminochrome neurotoxicity: glutathione transferase M2–2 and DT-diaphorase. Antioxidants (Basel) 11:296. https://doi.org/10.3390/antiox11020296. (PMID: 35204179)

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Escuela de Tecnología Médica, Facultad de Salud, Universidad Santo Tomás, Los Carreras 753, Osorno, Chile

    Sandro Huenchuguala

  2. Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile

    Juan Segura-Aguilar

Authors
  1. Sandro Huenchuguala
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  2. Juan Segura-Aguilar
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SH: editing, references, figure corrections; JSA: write manuscript, design and realization of the figure.

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Correspondence to Juan Segura-Aguilar.

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Commentary on: DOI: https://doi.org/10.1007/s00018-022-04574-x.

Juan Segura-Aguilar: Google Scholar: https://scholar.google.com/citations?user=_07ZLa4AAAAJ&hl=sv&oi=ao. Frontiers: https://loop.frontiersin.org/people/318600/overview. Research gate: https://www.researchgate.net/profile/Juan-Segura-Aguilar.

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Huenchuguala, S., Segura-Aguilar, J. Why are neuromelanin-containing dopaminergic neurons lost in idiopathic Parkinson’s disease?. Cell. Mol. Life Sci. 80, 281 (2023). https://doi.org/10.1007/s00018-023-04880-y

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  • DOI: https://doi.org/10.1007/s00018-023-04880-y

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