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Molecular regulation of hematopoietic stem cell quiescence

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Abstract

Hematopoietic stem cells (HSCs) are primarily dormant in a cell-cycle quiescence state to preserve their self-renewal capacity and long-term maintenance, which is essential for the homeostasis of hematopoietic system. Dysregulation of quiescence causes HSC dysfunction and may result in aberrant hematopoiesis (e.g., myelodysplastic syndrome and bone marrow failure syndromes) and leukemia transformation. Accumulating evidence indicates that both intrinsic molecular networks and extrinsic signals regulate HSC quiescence, including cell-cycle regulators, transcription factors, epigenetic factors, and niche factors. Further, the transition between quiescence and activation of HSCs is a continuous developmental path driven by cell metabolism (e.g., protein synthesis, glycolysis, oxidative phosphorylation, and autophagy). Elucidating the complex regulatory networks of HSC quiescence will expand the knowledge of HSC hemostasis and benefit for clinical HSC use. Here, we review the current understanding and progression on the molecular and metabolic regulation of HSC quiescence, providing a more complete picture regarding the mechanisms of HSC quiescence maintenance.

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Acknowledgements

This work was supported by grants from the National Key R&D Program of China (2017YFA0106700) and the National Science Foundation of China (82170115).

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National Key R&D Program of China, 2017YFA0106700, Yu Hou, National Science Foundation of China, 82170115, Yu Hou

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  1. Zhe Chen and Qian Guo contributed equally.

Authors and Affiliations

  1. Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, China

    Zhe Chen, Qian Guo & Yu Hou

  2. Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China

    Zhe Chen, Qian Guo & Yu Hou

  3. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China

    Guanbin Song

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  1. Zhe Chen
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ZC and QG wrote the manuscript. GBS and YH designed and revised the manuscript. All authors have approved this version of the article.

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Chen, Z., Guo, Q., Song, G. et al. Molecular regulation of hematopoietic stem cell quiescence. Cell. Mol. Life Sci. 79, 218 (2022). https://doi.org/10.1007/s00018-022-04200-w

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