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Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases

Cellular and Molecular Life Sciences volume 77, pages 3525–3546 (2020)Cite this article

Abstract

Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.

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Acknowledgements

Financial support from the National Natural Science Foundation of China (No. 81673296) and the start-up Foundation from Tianjin University of Science and Technology is gratefully acknowledged. KR acknowledges support from DFG and CRC1292.

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Authors and Affiliations

  1. Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China

    Dong Wang, Peng Yu & Laurent Désaubry

  2. Laboratory of Cardio-Oncology and Medicinal Chemistry (FRE 2033), CNRS, Institut Le Bel, 4 rue Blaise Pascal, CS 90032, 67081, Strasbourg, France

    Redouane Tabti, Sabria Elderwish, Hussein Abou-Hamdan, Amel Djehal, Canan G. Nebigil & Laurent Désaubry

  3. Superior National School Biotechnology Taoufik Khaznadar, Ville universitaire Ali Mendjeli, BP E66 25100, Constantine, Algeria

    Amel Djehal

  4. Cell Biology Unit, University Medical Center Mainz, JGU-Mainz, Mainz, Germany

    Hajime Yurugi & Krishnaraj Rajalingam

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  1. Dong Wang
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  2. Redouane Tabti
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  10. Laurent Désaubry
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Wang, D., Tabti, R., Elderwish, S. et al. Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases. Cell. Mol. Life Sci. 77, 3525–3546 (2020). https://doi.org/10.1007/s00018-020-03475-1

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  • DOI: https://doi.org/10.1007/s00018-020-03475-1

Keywords

  • Cell signaling
  • Scaffold proteins
  • MAP kinase
  • C-RAF
  • RAF1
  • KRAS
  • NF-kB
  • Wnt
  • LC3
  • Mitophagy
  • Cancer
  • Drug discovery
  • Inflammation
  • Cardiac diseases
  • Alzheimer disease
  • Parkinson disease
  • Autoimmune disease
  • Osteoporosis
  • Osteoclastogenesis
  • Cardio-oncology
  • Melanogenesis