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PEBP1/RKIP behavior: a mirror of actin-membrane organization

Abstract

Phosphatidylethanolamine-binding protein 1 (PEBP1), a small 21 kDa protein, is implicated in several key processes of the living cell. The deregulation of PEBP1, especially its downregulation, leads to major diseases such as cancer and Alzheimer’s disease. PEBP1 was found to interact with numerous proteins, especially kinases and GTPases, generally inhibiting their activity. To understand the basic functionality of this amazing small protein, we have considered several known processes that it modulates and we have discussed the role of each molecular target in these processes. Here, we propose that cortical actin organization, associated with membrane changes, is involved in the majority of the processes modulated by PEBP1. Furthermore, based on recent data, we summarize some key PEBP1-interacting proteins, and we report their respective functions and focus on their relationships with actin organization. We suggest that, depending on the cell status and environment, PEBP1 is an organizer of the actin-membrane composite material.

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Acknowledgements

We thank Isabelle Callebaut (IMPMC) for helpful comments and fruitful remarks. We sincerely thank William Sacks (IMPMC) for critical reading and improvement of the manuscript. We thank also the members of the “Canceropôle du grand Ouest” for stimulating and constructive discussions throughout these last few years.

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Schoentgen, F., Jonic, S. PEBP1/RKIP behavior: a mirror of actin-membrane organization. Cell. Mol. Life Sci. 77, 859–874 (2020). https://doi.org/10.1007/s00018-020-03455-5

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Keywords

  • Actin
  • Cytoskeleton
  • Membrane
  • Cell shape
  • Motility