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Introduction to the multi-author-review: emerging advances in the structural chemistry of DNA strand break repair

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Abstract

DNA strand breaks present a complex challenge for our cells, and the integrity of the DNA damage response machinery is critical for preventing cancer, premature aging, and neurodegenerative syndromes amongst other ailments. This multi-author review issue presents emerging topics relevant to understanding the fundamental structural mechanisms of DNA strand break sensing, signaling, and repair.

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Acknowledgements

This research was supported by the intramural research program of the US National Institutes of Health (NIH), National Institute of Environmental Health Sciences (NIEHS) Grant 1Z01ES102765 to R.S.W.

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  1. Department of Health and Human Services, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, Durham, NC, USA

    R. Scott Williams

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  1. R. Scott Williams
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Correspondence to R. Scott Williams.

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Williams, R.S. Introduction to the multi-author-review: emerging advances in the structural chemistry of DNA strand break repair. Cell. Mol. Life Sci. 77, 1–2 (2020). https://doi.org/10.1007/s00018-019-03364-2

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  • DOI: https://doi.org/10.1007/s00018-019-03364-2

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