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Bacterial stress defense: the crucial role of ribosome speed

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Abstract

In nature, bacteria are constantly adapting to various stressful conditions. Timely activation of stress response programs is crucial for bacteria to smoothly survive under stressful conditions. Stress response, demanding the de novo synthesis of many defense proteins, is generally activated at the transcriptional level by specific regulators. However, the effect of the global protein translational status on stress response has been largely overlooked. The translational capacity is limited by the number of translating ribosomes and the translational elongation rate. Recent work has shown that certain environmental stressors (e.g. oxidative stress) could severely compromise the stress response progress of bacteria by causing either slow-down or even complete stalling of the translational elongation process. The maintenance of ribosome elongation rate, being crucial for timely synthesis of stress defense proteins, becomes the physiological bottleneck that limits the survival of bacteria in some stressful conditions. Here, we briefly summarize some recent progress on the translational status of bacteria under two distinct stress conditions, nutrient deprivation and oxidative stress. We further discuss several important open questions on the translational regulation of bacteria during stress. The ribosome translation should be investigated in parallel with traditional transcriptional regulation in order to gain a better understanding on bacterial stress defense.

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Acknowledgements

This work was supported by the National Natural Science Fund of China (No. 31700089, No. 31970027, No. 31700039 and No. 31870028) and by self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (CCNU18QN028, CCNU18KFY01, CCNU19TS028 and CCNU18ZDPY05).

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  1. School of Life Sciences, Central China Normal University, Wuhan, Hubei, China

    Manlu Zhu & Xiongfeng Dai

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  1. Manlu Zhu
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Correspondence to Manlu Zhu or Xiongfeng Dai.

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Zhu, M., Dai, X. Bacterial stress defense: the crucial role of ribosome speed. Cell. Mol. Life Sci. 77, 853–858 (2020). https://doi.org/10.1007/s00018-019-03304-0

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