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Protein methylation functions as the posttranslational modification switch to regulate autophagy

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Abstract

Studies over the past decades have elucidated the critical role of autophagy in human health and diseases. Although the processes of autophagy in the cytoplasm have been well studied, the posttranscriptional and epigenetic regulation mechanisms of autophagy are still poorly understood. Protein methylation, including histone methylation and non-histone protein methylation, is the most important type of posttranscriptional and epigenetic modification. Recent studies have shown that protein methylation is associated with effects on autophagosome formation, autophagy-related protein expression, and signaling pathway activation, but the details are still unclear. Thus, it is important to summarize the current status and discuss the future directions of research on protein methylation in the context of autophagy.

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Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China (nos. 81600188, 81670050), Tongji Hospital Fund for Distinguished Young Scholars (no. 2016YQ02), and Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, HUST.

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  1. Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan, 430030, China

    Rui Li, Xiang Wei & Ding-Sheng Jiang

  2. Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China

    Xiang Wei & Ding-Sheng Jiang

  3. NHC Key Laboratory of Organ Transplantation, Ministry of Health, Wuhan, China

    Xiang Wei & Ding-Sheng Jiang

  4. Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China

    Xiang Wei & Ding-Sheng Jiang

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  1. Rui Li
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Li, R., Wei, X. & Jiang, DS. Protein methylation functions as the posttranslational modification switch to regulate autophagy. Cell. Mol. Life Sci. 76, 3711–3722 (2019). https://doi.org/10.1007/s00018-019-03161-x

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