Cellular and Molecular Life Sciences

, Volume 75, Issue 1, pp 81–82 | Cite as

Selected aspects of the human gut microbiota

  • Marco Ventura
  • Paul W. O’Toole
  • Willem M. de Vos
  • Douwe van SinderenEmail author
Multi-author review


The gut microbiota represents a highly complex assembly of microbes, which interact with each other and with their host. These interactions have various implications in terms of health and disease, and this multi-author review issue will address a number of selected aspects pertaining to gut microbiota research.


Microbiota Microbiome Probiotic Gut commensals Diet & health 


Author contributions

(1) Early microbiota, antibiotics and health. Alicja M. Nogacka, Nuria Salazar, Silvia Arboleya, Marta Suárez, Nuria Fernández, Gonzalo Solís, Clara G. de los Reyes-Gavilán, and Miguel Gueimonde. (2) Role of gut microbiota in aging-related health decline; insights from invertebrate models. Rebecca I. Clark and David W. Walker. (3) Bifidobacteria and the infant gut: an example of co-evolution and natural selection. Francesca Turroni, Christian Milani, Sabrina Duranti, Chiara Ferrario, Gabriele Andrea Lugli, Leonardo Mancabelli, Douwe van Sinderen, and Marco Ventura. (4) Microbiome–health interactions in older people. Paul O’Toole and Ian B. Jeffery. (5) Gut microbiota changes in the extreme decades of human life: a focus on centenarians. Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, and Claudio Franceschi. (6) Mouse models for human intestinal microbiota research: a critical evaluation. Floor Hugenholtz and Willem M de Vos.


  1. 1.
    Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R (2012) Diversity, stability and resilience of the human gut microbiota. Nature 489:220–230CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Bokulich NA, Chung J, Battaglia T, Henderson N, Jay M, Li HL, Lieber AD, Wu F, Perez-Perez GI, Chen Y, Schweizer W, Zheng XH, Contreras M, Dominguez-Bello MG, Blaser MJ (2016) Antibiotics, birth mode, and diet shape microbiome maturation during early life. Sci Transl Med 8:343ra82CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Yassour M, Vatanen T, Siljander H, Hamalainen AM, Harkonen T, Ryhanen SJ, Franzosa EA, Vlamakis H, Huttenhower C, Gevers D, Lander ES, Knip M, Group DS, Xavier RJ (2016) Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci Transl Med 8:343ra81CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI (2012) Human gut microbiome viewed across age and geography. Nature. 486:222–227PubMedPubMedCentralGoogle Scholar
  5. 5.
    Macpherson AJ, de Aguero MG, Ganal-Vonarburg SC (2017) How nutrition and the maternal microbiota shape the neonatal immune system. Nat Rev Immunol 17:508–517CrossRefPubMedGoogle Scholar
  6. 6.
    Planer JD, Peng Y, Kau AL, Blanton LV, Ndao IM, Tarr PI, Warner BB, Gordon JI (2016) Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice. Nature 534:263–266PubMedPubMedCentralGoogle Scholar
  7. 7.
    Tamboli CP, Neut C, Desreumaux P, Colombel JF (2004) Dysbiosis in inflammatory bowel disease. Gut 53:1–4CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Marco Ventura
    • 1
  • Paul W. O’Toole
    • 2
  • Willem M. de Vos
    • 3
    • 4
  • Douwe van Sinderen
    • 2
    • 5
    Email author
  1. 1.Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental SustainabilityMicrobiome Research Hub, University of ParmaParmaItaly
  2. 2.School of Microbiology, APC Microbiome InstituteUniversity College CorkCorkIreland
  3. 3.Laboratory of MicrobiologyWageningen UniversityWageningenThe Netherlands
  4. 4.Department of Bacteriology and ImmunologyUniversity of HelsinkiHelsinkiFinland
  5. 5.School of MicrobiologyNational University of IrelandCorkIreland

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