TUSC3: functional duality of a cancer gene

  • Kateřina Vašíčková
  • Peter Horak
  • Petr Vaňhara
Review

Abstract

Two decades ago, following a systematic screening of LOH regions on chromosome 8p22, TUSC3 has been identified as a candidate tumor suppressor gene in ovarian, prostate and pancreatic cancers. Since then, a growing body of evidence documented its clinical importance in various other types of cancers, and first initial insights into its molecular function and phenotypic effects have been gained, though the precise role of TUSC3 in different cancers remains unclear. As a part of the oligosaccharyltransferase complex, TUSC3 localizes to the endoplasmic reticulum and functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response. We are still trying to figure out how this mechanistic function is reconcilable with its varied effects on cancer promotion. In this review, we focus on cancer-related effects of TUSC3 and envisage a possible role of TUSC3 beyond endoplasmic reticulum.

Keywords

TUSC3 Cancer Tumor suppressor Oncogene Endoplasmic reticulum N-Glycosylation Immunoediting 

Notes

Author contributions

KV drafted the manuscript, PH and PV conceptualized, wrote and revised the manuscript.

Compliance with ethical standards

Funding

Grant Agency of Masaryk University (MUNI/A/1369/2016), European Regional Development Fund (Center for Analysis and Modeling of Tissues and Organs, CZ.1.07/2.3.00/20.0185), the National Program of Sustainability II (Project no. LQ1605, MEYS CR).

Conflict of interest

Authors declare no conflict of interest.

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Histology and Embryology, Faculty of MedicineMasaryk UniversityBrnoCzech Republic
  2. 2.International Clinical Research CenterSt. Anne’s University Hospital BrnoBrnoCzech Republic
  3. 3.Department of Translational OncologyNational Center for Tumor Diseases (NCT)HeidelbergGermany
  4. 4.German Cancer Research Center (DKFZ)HeidelbergGermany

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